Reviewed, UniProtKB/Swiss-Prot Q9D136 (YQ007_MOUSE)

Names and origin

Protein names	Recommended name:     PKHD domain-containing transmembrane protein FLJ22222 homolog     EC=1.14.-.-
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type II membrane proteinPotential.
Sequence similarities	Contains 1 PKHD (prolyl/lysyl hydroxylase) domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
PTM	Glycoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 315	315	PKHD domain-containing transmembrane protein FLJ22222 homolog
Regions
	Topological domain	1 – 41	41	Cytoplasmic Potential
	Transmembrane	42 – 62	21	Signal-anchor for type II membrane protein Potential
	Topological domain	63 – 315	253	Lumenal Potential
	Domain	104 – 302	199	PKHD
Sites
	Active site	294	1	Potential
	Metal binding	226	1	Iron By similarity
	Metal binding	228	1	Iron By similarity
	Metal binding	284	1	Iron By similarity
Amino acid modifications
	Glycosylation	211	1	N-linked (GlcNAc...) Potential
	Glycosylation	263	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9D136-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 7D4C5CD55F55EA36	FASTA	315	35,385
	10 20 30 40 50 60 MAPQRRGPPR IPEGSSAAER RRATSTKKDR LPREAQRTWL RIVAFGVGLA LVTCLLWSSV 70 80 90 100 110 120 GIDDDVAEVV ARRGEVLEGR FIEVPCSEDY DGHRRFEGCT PRKCGRGVTD IVITREEAEQ 130 140 150 160 170 180 IRRIAEKGLS LGGSDGGASI LDLHSGALSV GKHFVNLYRY FGDKIQNIFS EEDFQLYRDI 190 200 210 220 230 240 RQKVQLTIAE AFGISASLLY LTKPTFFSRI NSTEARTAHD EYWHAHVDKV TYGSFDYTSL 250 260 270 280 290 300 LYLSDYLEDF GGGRFVFMEE GSNKTVEPRA GRVSFFTSGS ENLHRVEKVL WGTRYAITIA 310 FTCNPDHGIE DPVLT

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: BALB/c and C57BL/6J. Tissue: Embryo and Placenta.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK004005 mRNA. Translation: BAB23119.1. AK145938 mRNA. Translation: BAE26768.1. AK168300 mRNA. Translation: BAE40241.1. BC024349 mRNA. Translation: AAH24349.1.
RefSeq	NP_079678.1.
UniGene	Mm.390403
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000025169. Mus musculus. [Contig view]
GeneID	66179.
KEGG	mmu:66179.
Organism-specific databases
MGI	MGI:1913429. 1110031I02Rik.
Phylogenomic databases
HOGENOM	Q9D136.
HOVERGEN	Q9D136.
Gene expression databases
ArrayExpress	Q9D136.
CleanEx	MM_1110031I02RIK.
Family and domain databases
InterPro	IPR006620. Pro_4_hyd_alph. [Graphical view]
SMART	SM00702. P4Hc. 1 hit. [Graphical view]
ProDom	Q9D136. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

YQ007_MOUSE

Accession

Primary (citable) accession number: Q9D136

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	June 1, 2001
Last modified:	July 22, 2008
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)