Reviewed, UniProtKB/Swiss-Prot Q9DCT6 (CQ049_MOUSE)

Names and origin

Protein names	Recommended name:     Uncharacterized potential DNA-binding protein C17orf49 homolog
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	NucleusPotential.
Sequence similarities	Contains 1 SANT domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	DNA-binding
PTM	Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9DCT6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9DCT6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     137-171: VTLSALNDSDANSDLVDVEGLGETPPAKKLNFDQA → SLTLDSGLLTTSADAPLLSC

Isoform 3 (identifier: Q9DCT6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     41-74: Missing.

Isoform 4 (identifier: Q9DCT6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     41-74: Missing.
     137-171: VTLSALNDSDANSDLVDVEGLGETPPAKKLNFDQA → SLTLDSGLLTTSADAPLLSC

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 171	171	Uncharacterized potential DNA-binding protein C17orf49 homolog
Regions
	Domain	38 – 83	46	SANT
Amino acid modifications
	Modified residue	96	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	41 – 74	34	Missing in isoform 3 and isoform 4.
	Alternative sequence	137 – 171	35	VTLSA…NFDQA → SLTLDSGLLTTSADAPLLSC in isoform 2 and isoform 4.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: E7D10D1429D0BABF	FASTA	171	17,996
	10 20 30 40 50 60 MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVSDSSPAGA KWTETEIEML RAAVKRFGDD 70 80 90 100 110 120 LNHISCVIKE RTVAQIKTTV KRKVYEDSGI PLPAESPKKG PKKMTSGVLS PPNAPPPSSS 130 140 150 160 170 SVPEAGVPPI KKQKADVTLS ALNDSDANSD LVDVEGLGET PPAKKLNFDQ A
	Isoform 2 [UniParc]. Checksum: 5C0E7A3235E3500C		156	16,330
	10 20 30 40 50 60 MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVSDSSPAGA KWTETEIEML RAAVKRFGDD 70 80 90 100 110 120 LNHISCVIKE RTVAQIKTTV KRKVYEDSGI PLPAESPKKG PKKMTSGVLS PPNAPPPSSS 130 140 150 SVPEAGVPPI KKQKADSLTL DSGLLTTSAD APLLSC
	Isoform 3 [UniParc]. Checksum: 2E8ACD3296217841		137	14,054
	10 20 30 40 50 60 MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVSDSSPAGA QIKTTVKRKV YEDSGIPLPA 70 80 90 100 110 120 ESPKKGPKKM TSGVLSPPNA PPPSSSSVPE AGVPPIKKQK ADVTLSALND SDANSDLVDV 130 EGLGETPPAK KLNFDQA
	Isoform 4 [UniParc]. Checksum: 686BA4E3F584A4DD		122	12,387
	10 20 30 40 50 60 MTSASTKVGE IFSAAGAAFT KLGELTMQLH PVSDSSPAGA QIKTTVKRKV YEDSGIPLPA 70 80 90 100 110 120 ESPKKGPKKM TSGVLSPPNA PPPSSSSVPE AGVPPIKKQK ADSLTLDSGL LTTSADAPLL SC

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4). Strain: C57BL/6J. Tissue: Embryo, Embryonic heart and Kidney.
[2]	The mouse genome sequencing consortium Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: NMRI. Tissue: Mammary gland.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK002491 mRNA. Translation: BAB22140.1. AK003842 mRNA. Translation: BAB23031.1. AK169173 mRNA. Translation: BAE40952.1. AK170380 mRNA. Translation: BAE41758.1. AL669869 Genomic DNA. Translation: CAI35229.1. AL669869 Genomic DNA. Translation: CAI35230.1. BC055357 mRNA. Translation: AAH55357.1.
RefSeq	NP_081033.1.
UniGene	Mm.39265
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000020831. Mus musculus. [Contig view]
GeneID	104457.
KEGG	mmu:104457.
NMPDR	fig|10090.3.peg.24551.
Organism-specific databases
MGI	MGI:1915609. 0610010K14Rik.
Phylogenomic databases
HOVERGEN	Q9DCT6.
Gene expression databases
CleanEx	MM_0610010K14RIK.
GermOnline	ENSMUSG00000020831. Mus musculus.
Family and domain databases
InterPro	IPR001005. SANT_DNA-bd. [Graphical view]
SMART	SM00717. SANT. 1 hit. [Graphical view]
PROSITE	PS51293. SANT. False negative. [Graphical view]
ProDom	Q9DCT6. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CQ049_MOUSE

Accession

Primary (citable) accession number: Q9DCT6
Secondary accession number(s): Q3TFE6, Q7TMP3, Q9D183

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	June 1, 2001
Last modified:	July 22, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)