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Reviewed, UniProtKB/Swiss-Prot Q9ERZ3 (ACM3_MOUSE)

Last modified July 22, 2008. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Muscarinic acetylcholine receptor M3
Alternative name(s):
    Mm3 mAChR
Gene names
Name: Chrm3
Synonyms: Chrm-3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length589 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Subcellular location

Cell membrane; Multi-pass membrane proteinBy similarity. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane proteinBy similarity. Basolateral cell membrane; Multi-pass membrane proteinBy similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 589589Muscarinic acetylcholine receptor M3

Regions

Topological domain1 – 6666Extracellular Potential
Transmembrane67 – 90241 Potential
Topological domain91 – 10313Cytoplasmic Potential
Transmembrane104 – 124212 Potential
Topological domain125 – 14117Extracellular Potential
Transmembrane142 – 163223 Potential
Topological domain164 – 18320Cytoplasmic Potential
Transmembrane184 – 206234 Potential
Topological domain207 – 22822Extracellular Potential
Transmembrane229 – 251235 Potential
Topological domain252 – 491240Cytoplasmic Potential
Transmembrane492 – 512216 Potential
Topological domain513 – 52614Extracellular Potential
Transmembrane527 – 546207 Potential
Topological domain547 – 58943Cytoplasmic Potential
Motif274 – 2807Basolateral sorting signal By similarity

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Glycosylation151N-linked (GlcNAc...) Potential
Glycosylation411N-linked (GlcNAc...) Potential
Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation521N-linked (GlcNAc...) Potential
Disulfide bond140 ↔ 220 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9ERZ3-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: AB782149EBEE7804

FASTA58966,212
        10         20         30         40         50         60 
MTLHSNSTTS PLFPNISSSW VHSPSEAGLP LGTVSQLDSY NISQTSGNFS SNDTSSDPLG 

        70         80         90        100        110        120 
GHTIWQVVFI AFLTGFLALV TIIGNILVIV AFKVNKQLKT VNNYFLLSLA CADLIIGVIS 

       130        140        150        160        170        180 
MNLFTTYIIM NRWALGNLAC DLWLSIDYVA SNASVMNLLV ISFDRYFSIT RPLTYRAKRT 

       190        200        210        220        230        240 
TKRAGVMIGL AWVISFVLWA PAILFWQYFV GKRTVPPGEC FIQFLSEPTI TFGTAIAAFY 

       250        260        270        280        290        300 
MPVTIMTILY WRIYKETEKR TKELAGLQAS GTEAEAENFV HPTGSSRSCS SYELQQQGTK 

       310        320        330        340        350        360 
RSSRRKYGGC HFWFTTKSWK PSAEQMDQDH SSSDSWNNND AAASLENSAS SDEEDIGSET 

       370        380        390        400        410        420 
RAIYSIVLKL PGHSTILNST KLPSSDNLQV PDKDLGTMDV ERNAHKLQAQ KSMDDRDNCQ 

       430        440        450        460        470        480 
KDFSKLPIQL ESAVDTAKTS DTNSSVDKTT AALPLSFKEA TLAKRFALKT RSQITKRKRM 

       490        500        510        520        530        540 
SLIKEKKAAQ TLSAILLAFI ITWTPYNIMV LVNTFCDSCI PKTYWNLGYW LCYINSTVNP 

       550        560        570        580 
VCYALCNKTF RTTFKMLLLC QCDKRKRRKQ QYQQRQSVIF HKRVPEQAL

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References

[1]"Isolation, sequence and functional expression of mouse muscarinic acetylcholine receptor genes."
Gomeza J., Wess J.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cultured neurons from mouse brain reproduce the muscarinic receptor profile of their tissue of origin."
Andre C., Dos Santos G., Koulakoff A.
Eur. J. Neurosci. 6:1691-1701(1994) [PubMed: 7874308] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 314-439.
Tissue: Brain.

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Cross-references

Sequence databases

AF264050 Genomic DNA. Translation: AAG14344.1.
S74908 mRNA. Translation: AAB33576.2.
RefSeqNP_150372.1.
UniGeneMm.342315

3D structure databases

HSSPHSSP built from PDB template 1HLL based on UniProtKB P08913.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

EnsemblENSMUSG00000046159. Mus musculus. [Contig view]
GeneID12671.
KEGGmmu:12671.

Organism-specific databases

MGIMGI:88398. Chrm3.

Phylogenomic databases

HOGENOMQ9ERZ3.
HOVERGENQ9ERZ3.

Gene expression databases

ArrayExpressQ9ERZ3.
CleanExMM_CHRM3.
GermOnlineENSMUSG00000046159. Mus musculus.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR001183. Musac_M3_rcpt.
IPR000995. Musac_rcpt.
[Graphical view]
PANTHERPTHR19266:SF37. Musac_M3_rcpt. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00243. MUSCARINICR.
PR00540. MUSCRINICM3R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProDomQ9ERZ3.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameACM3_MOUSE
AccessionPrimary (citable) accession number: Q9ERZ3
Secondary accession number(s): Q64055
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: July 22, 2008
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents