Reviewed, UniProtKB/Swiss-Prot Q9H2U9 (ADAM7_HUMAN)

Names and origin

Protein names

Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 7
      Short name=ADAM 7
Alternative name(s):
    Sperm maturation-related glycoprotein GP-83

Gene names

Name:	ADAM7
Synonyms:	GP83

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	754 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 1 disintegrin domain. Contains 1 peptidase M12B domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 176	158	By similarity
	Chain	177 – 754	578	Disintegrin and metalloproteinase domain-containing protein 7
Regions
	Topological domain	19 – 668	650	Extracellular Potential
	Transmembrane	669 – 689	21	Potential
	Topological domain	690 – 754	65	Cytoplasmic Potential
	Domain	199 – 394	196	Peptidase M12B
	Domain	402 – 488	87	Disintegrin
	Compositional bias	489 – 668	180	Cys-rich
Amino acid modifications
	Glycosylation	84	1	N-linked (GlcNAc...) Potential
	Glycosylation	167	1	N-linked (GlcNAc...) Potential
	Glycosylation	174	1	N-linked (GlcNAc...) Potential
	Glycosylation	184	1	N-linked (GlcNAc...) Potential
	Glycosylation	584	1	N-linked (GlcNAc...) Potential
	Glycosylation	668	1	N-linked (GlcNAc...) Potential
	Disulfide bond	310 ↔ 389		By similarity
	Disulfide bond	350 ↔ 373		By similarity
	Disulfide bond	352 ↔ 357		By similarity
	Disulfide bond	460 ↔ 480		By similarity
Experimental info
	Sequence conflict	369 – 370	2	KF → DL in AAC36742. Ref.2
	Sequence conflict	374	1	S → R in AAC36742. Ref.2
	Sequence conflict	518	1	D → E in AAC36742. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9H2U9-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 64D04B8C7992E281	FASTA	754	85,583
	10 20 30 40 50 60 MLPGCIFLMI LLIPQVKEKF ILGVEGQQLV RPKKLPLIQK RDTGHTHDDD ILKTYEEELL 70 80 90 100 110 120 YEIKLNRKTL VLHLLRSREF LGSNYSETFY SMKGGAFTRH PQIMDHCFYQ GSIVHEYDSA 130 140 150 160 170 180 ASISTCNGLR GFFRINDQRY LIEPVKYSDE GEHLVFKYNL RVPYGANYSC TELNFTRKTV 190 200 210 220 230 240 PGDNESEEDS KIKGIHDEKY VELFIVADDT VYRRNGHPHN KLRNRIWGMV NFVNMIYKTL 250 260 270 280 290 300 NIHVTLVGIE IWTHEDKIEL YSNIETTLLR FSFWQEKILK TRKDFDHVVL LSGKWLYSHV 310 320 330 340 350 360 QGISYPGGMC LPYYSTSIIK DLLPDTNIIA NRMAHQLGHN LGMQHDEFPC TCPSGKCVMD 370 380 390 400 410 420 SDGSIPALKF SKCSQNQYHQ YLKDYKPTCM LNIPFPYNFH DFQFCGNKKL DEGEECDCGP 430 440 450 460 470 480 AQECTNPCCD AHTCVLKPGF TCAEGECCES CQIKKAGSIC RPAKDECDFP EMCTGHSPAC 490 500 510 520 530 540 PKDQFRVNGF PCKNSEGYCF MGKCPTREDQ CSELFDDDAI ESHDICYKMN TKGNKFGYCK 550 560 570 580 590 600 NKENRFLPCE EKDVRCGKIY CTGGELSSLL GEDKTYHLKD PQKNATVKCK TIFLYHDSTD 610 620 630 640 650 660 IGLVASGTKC GEGMVCNNGE CLNMEKVYIS TNCPSQCNEN PVDGHGLQCH CEEGQAPVAC 670 680 690 700 710 720 EETLHVTNIT ILVVVLVLVI VGIGVLILLV RYRKCIKLKQ VQSPPTETLG VENKGYFGDE 730 740 750 QQIRTEPILP EIHFLNKPAS KDSRGIADPN QSAK

References

[1]	"Expression of human ADAM7 (GP-83)." Lin Y.C., Lee Y.M., Sun G.H., Liu H.W. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Epididymis.
[2]	"A ADAM-like cDNA sequence identified in cDNA library of human epididymis." Liu H.W., Lin Y.C., Sun G.H. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 167-754. Tissue: Epididymis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF215824 mRNA. Translation: AAG43987.1. AF090327 mRNA. Translation: AAC36742.1.
RefSeq	NP_003808.2.
UniGene	Hs.116147
3D structure databases
HSSP	HSSP built from PDB template 1FVL based on UniProtKB P18619.
ModBase	Search...
Protein family/group databases
MEROPS	M12.956.
Genome annotation databases
Ensembl	ENSG00000069206. Homo sapiens. [Contig view]
GeneID	8756.
KEGG	hsa:8756.
Organism-specific databases
HGNC	HGNC:214. ADAM7.
MIM	607310. gene.
PharmGKB	PA24532.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q9H2U9.
Gene expression databases
ArrayExpress	Q9H2U9.
CleanEx	HS_ADAM7.
GermOnline	ENSG00000069206. Homo sapiens.
Family and domain databases
InterPro	IPR006586. ADAM_cysteine. IPR001762. Blood-coag_inhib_Disintegrin. IPR001590. Peptidase_M12B. IPR002870. Peptidase_M12B_N. [Graphical view]
Gene3D	G3DSA:4.10.70.10. Blood-coag_inhib_Disintegrin. 1 hit.
Pfam	PF08516. ADAM_CR. 1 hit. PF00200. Disintegrin. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. [Graphical view]
PRINTS	PR00289. DISINTEGRIN.
ProDom	PD000664. Disintegrin. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00608. ACR. 1 hit. SM00050. DISIN. 1 hit. [Graphical view]
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS00427. DISINTEGRIN_1. 1 hit. PS50214. DISINTEGRIN_2. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

ADAM7_HUMAN

Accession

Primary (citable) accession number: Q9H2U9
Secondary accession number(s): O75959

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	March 1, 2001
Last modified:	July 22, 2008
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)