Reviewed, UniProtKB/Swiss-Prot Q9IA23 (HXA5_HETFR)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A5

Gene names

Name:

HOXA5

Organism

Heterodontus francisci (Horn shark)

Taxonomic identifier

7792 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Galeomorphii › Heterodontoidea › Heterodontiformes › Heterodontidae › Heterodontus

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	NucleusBy similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 275	275	Homeobox protein Hox-A5
Regions
	DNA binding	200 – 259	60	Homeobox
	Motif	181 – 186	6	Antp-type hexapeptide
	Compositional bias	75 – 78	4	Poly-Ala
	Compositional bias	81 – 84	4	Poly-Ala
	Compositional bias	134 – 142	9	Poly-Ser
	Compositional bias	227 – 230	4	Poly-Arg

Sequences

	Sequence		Length	Mass (Da)
	Q9IA23-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 51BC2720808A31B6	FASTA	275	30,214
	10 20 30 40 50 60 MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQYRDSATM HSSRYGYGYN GMDLSISRPA 70 80 90 100 110 120 SNHFNASERS RSYSAAAATT AAAAGPEAGA DTRYNQPATS SPSPDPLPCS AVVSPSAGDN 130 140 150 160 170 180 HHGIKNSIAS PTTSSNSSSS SSHISRDGVG TSPGTEDDTP ASSDPPSSQN GQSTAQQQPQ 190 200 210 220 230 240 IYPWMRKLHI SHDSMGGPEG KRARTAYTRY QTLELEKEFH FNRYLTRRRR IEIAHALCLT 250 260 270 ERQIKIWFQN RRMKWKKDNK LKSMSMAAAG GGYRP

References

[1]

"Hox cluster genomics in the horn shark, Heterodontus francisci." Kim C.B., Amemiya C., Bailey W., Kawasaki K., Mezey J., Miller W., Minoshima S., Shimizu N., Wagner G., Ruddle F. Proc. Natl. Acad. Sci. U.S.A. 97:1655-1660(2000) [PubMed: 10677514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF224262 Genomic DNA. Translation: AAF44643.1.
3D structure databases
HSSP	HSSP built from PDB template 1SAN based on UniProtKB P02833.
SMR	Q9IA23. Positions 201-262.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q9IA23.
Family and domain databases
InterPro	IPR001827. Antennapedia. IPR001356. Homeobox. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
ProDom	PD000010. Homeobox. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

HXA5_HETFR

Accession

Primary (citable) accession number: Q9IA23

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2001
Last sequence update:	October 1, 2000
Last modified:	July 22, 2008
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)