Reviewed, UniProtKB/Swiss-Prot Q9JHJ3 (CA085_MOUSE)

Names and origin

Protein names	Recommended name:     Uncharacterized protein C1orf85 homolog Alternative name(s):     Protein NCU-G1
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Does not seem to be involved in inflammatory regulation.
Subcellular location	Membrane; Single-pass type I membrane proteinPotential.
Tissue specificity	Highly expressed high in kidneys, with highest expression in the cortex. Expressed in liver.
Developmental stage	Expressed at all stages of development tested.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 35	35	Potential
	Chain	36 – 404	369	Uncharacterized protein C1orf85 homolog
Regions
	Topological domain	36 – 370	335	Extracellular Potential
	Transmembrane	371 – 391	21	Potential
	Topological domain	392 – 404	13	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	64	1	N-linked (GlcNAc...) Potential
	Glycosylation	85	1	N-linked (GlcNAc...) Potential
	Glycosylation	157	1	N-linked (GlcNAc...) Potential
	Glycosylation	228	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	21	1	L → I in BAC35859. Ref.2
	Sequence conflict	52	1	P → T in BAE29857. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9JHJ3-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 65D490B53880B8B3	FASTA	404	43,804
	10 20 30 40 50 60 MFRCWGPHWG WVPCAPTPWL LLSLLVCSAP FGLQGEETRQ VSMEVISGWP NPQNLLHIRA 70 80 90 100 110 120 VGSNSTLHYV WSSLGPPAVV LVATNTTQSV LSVNWSLLLS PDPAGALMVL PKSSIQFSSA 130 140 150 160 170 180 LVFTRLLEFD STNASEGAQP PGKPYPPYSL AKFSWNNITN SLDLANLSAD FQGRPVDDPT 190 200 210 220 230 240 GAFANGSLTF KVQAFSRSGR PAQPPRLLHT ADVCQLEVAL VGASPRGNHS LFGLEVATLG 250 260 270 280 290 300 QGPDCPSVNE RNSIDDEYAP AVFQLNQLLW GSSPSGFMQW RPVAFSEEER ARESALPCQA 310 320 330 340 350 360 STLHSTLASS LPHSPIVQAF FGSQNNFCAF NLTFGAPTGP GYWDQYYLCW SMLLGMGFPP 370 380 390 400 VDIFSPLVLG IMAVALGAPG LMFLGGGLFL LLRHRRYSEY QSIN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA of a novel mRNA expressed predominantly in mouse kidney." Kawamura T., Kuroda N., Kimura Y., Lazoura E., Okada N., Okada H. Biochem. Genet. 39:33-42(2001) [PubMed: 11444019] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: BALB/c. Tissue: Liver.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Bone marrow, Dendritic cell, Head, Liver and Spleen.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB027141 mRNA. Translation: BAA92527.1. AB027142 mRNA. Translation: BAA95676.1. AK075614 mRNA. Translation: BAC35859.1. AK150794 mRNA. Translation: BAE29857.1. AK154340 mRNA. Translation: BAE32526.1. AK160793 mRNA. Translation: BAE36016.1. AK170696 mRNA. Translation: BAE41960.1. AK171042 mRNA. Translation: BAE42207.1. BC021547 mRNA. Translation: AAH21547.1.
RefSeq	NP_064387.1.
UniGene	Mm.439922
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000001418. Mus musculus. [Contig view]
GeneID	56700.
KEGG	mmu:56700.
Organism-specific databases
MGI	MGI:1913318. 0610031J06Rik.
Phylogenomic databases
HOVERGEN	Q9JHJ3.
Gene expression databases
CleanEx	MM_0610031J06RIK.
Family and domain databases
ProDom	Q9JHJ3. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CA085_MOUSE

Accession

Primary (citable) accession number: Q9JHJ3
Secondary accession number(s): Q3TUF5, Q3UBV7, Q8C6H7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	October 1, 2000
Last modified:	July 22, 2008
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)