Reviewed, UniProtKB/Swiss-Prot Q9N2A7 (ACM2_PANTR)

Names and origin

Protein names

Recommended name:
    Muscarinic acetylcholine receptor M2

Gene names

Name:

CHRM2

Organism

Pan troglodytes (Chimpanzee)

Taxonomic identifier

9598 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan

Protein attributes

Sequence length	440 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
Subcellular location	Cell membrane; Multi-pass membrane protein. Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Postsynaptic cell membrane Synapse
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	‹1 – 440	›440	Muscarinic acetylcholine receptor M2
Regions
	Transmembrane	‹1 – 19	›19	1 Potential
	Topological domain	20 – 33	14	Cytoplasmic Potential
	Transmembrane	34 – 54	21	2 Potential
	Topological domain	55 – 71	17	Extracellular Potential
	Transmembrane	72 – 93	22	3 Potential
	Topological domain	94 – 113	20	Cytoplasmic Potential
	Transmembrane	114 – 136	23	4 Potential
	Topological domain	137 – 158	22	Extracellular Potential
	Transmembrane	159 – 181	23	5 Potential
	Topological domain	182 – 362	181	Cytoplasmic Potential
	Transmembrane	363 – 383	21	6 Potential
	Topological domain	384 – 397	14	Extracellular Potential
	Transmembrane	398 – 417	20	7 Potential
	Topological domain	418 – 440	23	Cytoplasmic Potential
Amino acid modifications
	Modified residue	206	1	Phosphoserine By similarity
	Modified residue	208	1	Phosphoserine By similarity
	Modified residue	420	1	Phosphothreonine Potential
	Modified residue	424	1	Phosphothreonine Potential
	Modified residue	439	1	Phosphothreonine Potential
	Disulfide bond	70 ↔ 150		By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	Q9N2A7-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 12B0324E13D37DDF	FASTA	440	48,854
	10 20 30 40 50 60 VLVAGSLSLV TIIGNILVMV SIKVNRHLQT VNNYFLFSLA CADLIIGVFS MNLYTLYTVI 70 80 90 100 110 120 GYWPLGPVVC DLWLALDYVV SNASVMNLLI ISFDRYFCVT KPLTYPVKRT TKMAGMMIAA 130 140 150 160 170 180 AWVLSFILWA PAILFWQFIV GVRTVEDGEC YIQFFSNAAV TFGTAIAAFY LPVIIMTVLY 190 200 210 220 230 240 WHISRASKSR IKKDKKEPVA NQDPVSPSLV QGRIVKPNNN NMPSSDDGLE HNKIQNGKAP 250 260 270 280 290 300 RDPVTENCVQ GEEKESSNDS TSVSAVASNM RDDEITQDEN TVSTSLGHSK DENSKQTCIR 310 320 330 340 350 360 IGTKTPKSDS CTPTNTTVEV VGSSGQNGDE KQNIVARKIV KMTKQPAKKK PPPSREKKVT 370 380 390 400 410 420 RTILAILLAF IITWAPYNVM VLINTFCAPC IPNTVWTIGY WLCYINSTIN PACYALCNAT 430 440 FKKTFKHLLM CHYKNIGATR

References

[1]	"Silver project." Kitano T., Kobayakawa H., Saitou N. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Isolate 220.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB041392 Genomic DNA. Translation: BAA94477.1.
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Genome annotation databases
Ensembl	ENSPTRG00000019734. Pan troglodytes. [Contig view]
Phylogenomic databases
HOVERGEN	Q9N2A7.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR001065. Musac_M2_rcpt. IPR000995. Musac_rcpt. [Graphical view]
PANTHER	PTHR19266:SF32. Musac_M2_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00243. MUSCARINICR. PR00539. MUSCRINICM2R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACM2_PANTR

Accession

Primary (citable) accession number: Q9N2A7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2003
Last sequence update:	October 1, 2000
Last modified:	July 22, 2008
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)