Reviewed, UniProtKB/Swiss-Prot Q9NPA0 (CO024_HUMAN)

Names and origin

Protein names

Recommended name:
    UPF0480 protein C15orf24

Gene names

Name:	C15orf24
Synonyms:	C11orf3
ORF Names:	HT022, UNQ905/PRO1926

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane proteinPotential.
Sequence similarities	Belongs to the UPF0480 family.
Caution	Has been termed C11orf3 (Ref.1), but is not the official C11orf3 as defined by HGNC and furthermore maps to chromosome 15.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Technical term	3D-structure
Gene Ontology (GO)
Cellular component	cytoplasm Ref.1 Non-traceable author statement. Source: UniProtKB integral to membrane Ref.4 Non-traceable author statement. Source: UniProtKB
Molecular function	purine nucleotide binding Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 242	219	UPF0480 protein C15orf24
Regions
	Topological domain	24 – 159	136	Extracellular Potential
	Transmembrane	160 – 180	21	Potential
	Topological domain	181 – 242	62	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9NPA0-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: A71930B89A4C2458	FASTA	242	26,471
	10 20 30 40 50 60 MAAALWGFFP VLLLLLLSGD VQSSEVPGAA AEGSGGSGVG IGDRFKIEGR AVVPGVKPQD 70 80 90 100 110 120 WISAARVLVD GEEHVGFLKT DGSFVVHDIP SGSYVVEVVS PAYRFDPVRV DITSKGKMRA 130 140 150 160 170 180 RYVNYIKTSE VVRLPYPLQM KSSGPPSYFI KRESWGWTDF LMNPMVMMMV LPLLIFVLLP 190 200 210 220 230 240 KVVNTSDPDM RREMEQSMNM LNSNHELPDV SEFMTRLFSS KSSGKSSSGS SKTGKSGAGK RR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of five novel human genes in the 11q13-q22 region." O'Brien K.P., Tapia-Paez I., Staahle-Baeckdahl M., Kedra D., Dumanski J.P. Biochem. Biophys. Res. Commun. 273:90-94(2000) [PubMed: 10873569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Full-length of some new muscular transcript." Ievolella C., Lanfranchi G. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Muscle.
[3]	Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hypothalamus.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex and Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AJ250344 mRNA. Translation: CAB96539.1.
AJ245874 mRNA. Translation: CAC01611.1.
AF242729 mRNA. Translation: AAG44477.1.
AY358445 mRNA. Translation: AAQ88810.1.
BC012456 mRNA. Translation: AAH12456.1.
BC104934 mRNA. Translation: AAI04935.1.
BC104936 mRNA. Translation: AAI04937.1.

RefSeq

NP_064539.1.

UniGene

Hs.160565

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2UWE	X-ray	2.40	C/J	4-12	[»]

ModBase

Search...

Genome annotation databases

Ensembl

ENSG00000134153. Homo sapiens. [Contig view]

GeneID

56851.

KEGG

hsa:56851.

Organism-specific databases

HGNC

HGNC:24301. C15orf24.

HPA

HPA010029.

PharmGKB

PA134900493.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

Q9NPA0.

HOVERGEN

Q9NPA0.

Gene expression databases

ArrayExpress

Q9NPA0.

CleanEx

HS_C15orf24.

GermOnline

ENSG00000134153. Homo sapiens.

Family and domain databases

ProDom

Q9NPA0.
[Graphical view] [Entries sharing at least one domain]

BLOCKS

Search...

Other Resources

ProtoNet

Search...

Entry information

Entry name

CO024_HUMAN

Accession

Primary (citable) accession number: Q9NPA0
Secondary accession number(s): Q96ED5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 1, 2000
Last modified:	July 22, 2008
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)