Reviewed, UniProtKB/Swiss-Prot Q9NR00 (CH004_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C8orf4
Alternative name(s):
    Thyroid cancer protein 1
      Short name(s)=TC-1

Gene names

Name:	C8orf4
Synonyms:	TC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	106 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May decrease apoptosis.
Subunit structure	Monomer.
Tissue specificity	Ubiquitous. Expressed in thyroid papillary carcinoma.

Ontologies

Keywords
Biological process	Apoptosis
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 106	106	Uncharacterized protein C8orf4

Sequences

	Sequence		Length	Mass (Da)
	Q9NR00-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3EF7100FDA640599	FASTA	106	12,351
	10 20 30 40 50 60 MKAKRSHQAI IMSTSLRVSP SIHGYHFDTA SRKKAVGNIF ENTDQESLER LFRNSGDKKA 70 80 90 100 EERAKIIFAI DQDVEEKTRA LMALKKRTKD KLFQFLKLRK YSIKVH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer." Chua E.L., Young L., Wu W.M., Turtle J.R., Dong Q. Genomics 69:342-347(2000) [PubMed: 11056052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Thyroid papillary carcinoma.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Urinary bladder.
[3]	"TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer." Sunde M., McGrath K.C.Y., Young L., Matthews J.M., Chua E.L., Mackay J.P., Death A.K. Cancer Res. 64:2766-2773(2004) [PubMed: 15087392] [Abstract] Cited for: FUNCTION, SUBUNIT.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF268037 mRNA. Translation: AAF78961.1. BC020623 mRNA. Translation: AAH20623.1. BC021672 mRNA. Translation: AAH21672.1.
RefSeq	NP_064515.1.
UniGene	Hs.591849
3D structure databases
DisProt	DP00372.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000176907. Homo sapiens. [Contig view]
GeneID	56892.
KEGG	hsa:56892.
Organism-specific databases
HGNC	HGNC:1357. C8orf4.
MIM	607702. gene.
PharmGKB	PA25962.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	Q9NR00.
HOVERGEN	Q9NR00.
Gene expression databases
ArrayExpress	Q9NR00.
CleanEx	HS_C8orf4.
GermOnline	ENSG00000176907. Homo sapiens.
Family and domain databases
ProDom	Q9NR00. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	Q9NR00.
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

CH004_HUMAN

Accession

Primary (citable) accession number: Q9NR00

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 1, 2000
Last modified:	July 22, 2008
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)