Bromodomain adjacent to zinc finger domain protein 1A

Names and origin

Protein names

Recommended name:
    Bromodomain adjacent to zinc finger domain protein 1A
Alternative name(s):
    ATP-utilizing chromatin assembly and remodeling factor 1
      Short name=hACF1
    ATP-dependent chromatin-remodeling protein
    Williams syndrome transcription factor-related chromatin-remodeling factor 180
      Short name=WCRF180
      Short name=hWALp1
    CHRAC subunit ACF1

Gene names

Name:	BAZ1A
Synonyms:	ACF1, WCRF180
ORF Names:	HSPC317

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length	1556 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Function	May play a role in transcriptional regulation. May be involved in the formation or maintenance of heterochromatin playing a critical role in developmental control.
Subunit structure	Together with CHRAC1, POLE3 and SMARCA5 proteins, it forms the ISWI chromatin-remodeling complex, CHRAC.
Subcellular location	Nucleus. Note= May target the CHRAC complex to heterochromatin.
Tissue specificity	Highly expressed in testis and at low or undetectable levels in other tissues analyzed.
Miscellaneous	Stimulated by double-stranded DNA and nucleosomal DNA.
Sequence similarities	Belongs to the WAL family. Contains 1 bromo domain. Contains 1 DDT domain. Contains 1 PHD-type zinc finger. Contains 1 WAC domain.
Sequence caution	The sequence AAF28995.1 differs from that shown. Reason: Frameshift at several positions.

Hide | Top

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Bromodomain Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Hide | Top

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NRL2-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NRL2-2) The sequence of this isoform differs from the canonical sequence as follows: 504-535: Missing.

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Chain

1 – 1556

1556

Bromodomain adjacent to zinc finger domain protein 1A

Regions

Domain

22 – 128

107

WAC

Domain

422 – 487

66

DDT

Domain

1446 – 1516

71

Bromo

Zinc finger

1148 – 1198

51

PHD-type

Coiled coil

306 – 397

92

Potential

Coiled coil

634 – 709

76

Potential

Amino acid modifications

Modified residue

606

1

Phosphotyrosine

Modified residue

1413

1

Phosphoserine

Modified residue

1417

1

Phosphoserine

Natural variations

Alternative sequence

504 – 535

32

Missing in isoform 2.

Natural variant

344

1

D → E: dbSNP rs1133285.

Experimental info

Sequence conflict

135

1

R → T in BAA89209. Ref.3

Sequence conflict

236

1

D → E in BAA89209. Ref.3

Sequence conflict

494

1

K → Q in AAF28995. Ref.4

Sequence conflict

503 – 508

6

KDLTEA → QDFTEP in AAF28995. Ref.4

Sequence conflict

525

1

S → P in AAF28995. Ref.4

Sequence conflict

536 – 540

5

GCSLK → AALKF in AAF28995. Ref.4

Sequence conflict

551

1

E → D in AAF70601. Ref.1

Sequence conflict

730

1

V → F in BAA89209. Ref.3

Sequence conflict

769

1

P → L in BAA89209. Ref.3

Sequence conflict

1201

1

S → C in BAA89209. Ref.3

Sequence conflict

1206

1

S → F in BAA89209. Ref.3

Sequence conflict

1366

1

N → K in AAF70601. Ref.1

Sequence conflict

1366

1

N → K in CAB43261. Ref.5

Sequence conflict

1409

1

R → K in AAF70601. Ref.1

Sequence conflict

1409

1

R → K in CAB43261. Ref.5

Hide | Top

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 4D78B9A8ADBF715B Show »	FASTA	1,556	178,702
10 20 30 40 50 60 MPLLHRKPFV RQKPPADLRP DEEVFYCKVT NEIFRHYDDF FERTILCNSL VWSCAVTGRP 70 80 90 100 110 120 GLTYQEALES EKKARQNLQS FPEPLIIPVL YLTSLTHRSR LHEICDDIFA YVKDRYFVEE 130 140 150 160 170 180 TVEVIRNNGA RLQCRILEVL PPSHQNGFAN GHVNSVDGET IIISDSDDSE TQSCSFQNGK 190 200 210 220 230 240 KKDAIDPLLF KYKVQPTKKE LHESAIVKAT QISRRKHLFS RDKLKLFLKQ HCEPQDGVIK 250 260 270 280 290 300 IKASSLSTYK IAEQDFSYFF PDDPPTFIFS PANRRRGRPP KRIHISQEDN VANKQTLASY 310 320 330 340 350 360 RSKATKERDK LLKQEEMKSL AFEKAKLKRE KADALEAKKK EKEDKEKKRE ELKKIVEEER 370 380 390 400 410 420 LKKKEEKERL KVEREKEREK LREEKRKYVE YLKQWSKPRE DMECDDLKEL PEPTPVKTRL 430 440 450 460 470 480 PPEIFGDALM VLEFLNAFGE LFDLQDEFPD GVTLEVLEEA LVGNDSEGPL CELLFFFLTA 490 500 510 520 530 540 IFQAIAEEEE EVAKEQLTDA DTKDLTEALD EDADPTKSAL SAVASLAAAW PQLHQGCSLK 550 560 570 580 590 600 SLDLDSCTLS EILRLHILAS GADVTSANAK YRYQKRGGFD ATDDACMELR LSNPSLVKKL 610 620 630 640 650 660 SSTSVYDLTP GEKMKILHAL CGKLLTLVST RDFIEDYVDI LRQAKQEFRE LKAEQHRKER 670 680 690 700 710 720 EEAAARIRKR KEEKLKEQEQ KMKEKQEKLK EDEQRNSTAD ISIGEEERED FDTSIESKDT 730 740 750 760 770 780 EQKELDQDMV TEDEDDPGSH KRGRRGKRGQ NGFKEFTRQE QINCVTREPL TADEEEALKQ 790 800 810 820 830 840 EHQRKEKELL EKIQSAIACT NIFPLGRDRM YRRYWIFPSI PGLFIEEDYS GLTEDMLLPR 850 860 870 880 890 900 PSSFQNNVQS QDPQVSTKTG EPLMSESTSN IDQGPRDHSV QLPKPVHKPN RWCFYSSCEQ 910 920 930 940 950 960 LDQLIEALNS RGHRESALKE TLLQEKSRIC AQLARFSEEK FHFSDKPQPD SKPTYSRGRS 970 980 990 1000 1010 1020 SNAYDPSQMC AEKQLELRLR DFLLDIEDRI YQGTLGAIKV TDRHIWRSAL ESGRYELLSE 1030 1040 1050 1060 1070 1080 ENKENGIIKT VNEDVEEMEI DEQTKVIVKD RLLGIKTETP STVSTNASTP QSVSSVVHYL 1090 1100 1110 1120 1130 1140 AMALFQIEQG IERRFLKAPL DASDSGRSYK TVLDRWRESL LSSASLSQVF LHLSTLDRSV 1150 1160 1170 1180 1190 1200 IWSKSILNAR CKICRKKGDA ENMVLCDGCD RGHHTYCVRP KLKTVPEGDW FCPECRPKQR 1210 1220 1230 1240 1250 1260 SRRLSSRQRP SLESDEDVED SMGGEDDEVD GDEEEGQSEE EEYEVEQDED DSQEEEEVSL 1270 1280 1290 1300 1310 1320 PKRGRPQVRL PVKTRGKLSS SFSSRGQQQE PGRYPSRSQQ STPKTTVSSK TGRSLRKINS 1330 1340 1350 1360 1370 1380 APPTETKSLR IASRSTRHSH GPLQADVFVE LLSPRRKRRG RKSANNTPEN SPNFPNFRVI 1390 1400 1410 1420 1430 1440 ATKSSEQSRS VNIASKLSLQ ESESKRRCRK RQSPEPSPVT LGRRSSGRQG GVHELSAFEQ 1450 1460 1470 1480 1490 1500 LVVELVRHDD SWPFLKLVSK IQVPDYYDII KKPIALNIIR EKVNKCEYKL ASEFIDDIEL 1510 1520 1530 1540 1550 MFSNCFEYNP RNTSEAKAGT RLQAFFHIQA QKLGLHVTPS NVDQVSTPPA AKKSRI « Hide
Isoform 2 [UniParc]. Checksum: 2DB787369178282B Show »		1,524	175,385
10 20 30 40 50 60 MPLLHRKPFV RQKPPADLRP DEEVFYCKVT NEIFRHYDDF FERTILCNSL VWSCAVTGRP 70 80 90 100 110 120 GLTYQEALES EKKARQNLQS FPEPLIIPVL YLTSLTHRSR LHEICDDIFA YVKDRYFVEE 130 140 150 160 170 180 TVEVIRNNGA RLQCRILEVL PPSHQNGFAN GHVNSVDGET IIISDSDDSE TQSCSFQNGK 190 200 210 220 230 240 KKDAIDPLLF KYKVQPTKKE LHESAIVKAT QISRRKHLFS RDKLKLFLKQ HCEPQDGVIK 250 260 270 280 290 300 IKASSLSTYK IAEQDFSYFF PDDPPTFIFS PANRRRGRPP KRIHISQEDN VANKQTLASY 310 320 330 340 350 360 RSKATKERDK LLKQEEMKSL AFEKAKLKRE KADALEAKKK EKEDKEKKRE ELKKIVEEER 370 380 390 400 410 420 LKKKEEKERL KVEREKEREK LREEKRKYVE YLKQWSKPRE DMECDDLKEL PEPTPVKTRL 430 440 450 460 470 480 PPEIFGDALM VLEFLNAFGE LFDLQDEFPD GVTLEVLEEA LVGNDSEGPL CELLFFFLTA 490 500 510 520 530 540 IFQAIAEEEE EVAKEQLTDA DTKGCSLKSL DLDSCTLSEI LRLHILASGA DVTSANAKYR 550 560 570 580 590 600 YQKRGGFDAT DDACMELRLS NPSLVKKLSS TSVYDLTPGE KMKILHALCG KLLTLVSTRD 610 620 630 640 650 660 FIEDYVDILR QAKQEFRELK AEQHRKEREE AAARIRKRKE EKLKEQEQKM KEKQEKLKED 670 680 690 700 710 720 EQRNSTADIS IGEEEREDFD TSIESKDTEQ KELDQDMVTE DEDDPGSHKR GRRGKRGQNG 730 740 750 760 770 780 FKEFTRQEQI NCVTREPLTA DEEEALKQEH QRKEKELLEK IQSAIACTNI FPLGRDRMYR 790 800 810 820 830 840 RYWIFPSIPG LFIEEDYSGL TEDMLLPRPS SFQNNVQSQD PQVSTKTGEP LMSESTSNID 850 860 870 880 890 900 QGPRDHSVQL PKPVHKPNRW CFYSSCEQLD QLIEALNSRG HRESALKETL LQEKSRICAQ 910 920 930 940 950 960 LARFSEEKFH FSDKPQPDSK PTYSRGRSSN AYDPSQMCAE KQLELRLRDF LLDIEDRIYQ 970 980 990 1000 1010 1020 GTLGAIKVTD RHIWRSALES GRYELLSEEN KENGIIKTVN EDVEEMEIDE QTKVIVKDRL 1030 1040 1050 1060 1070 1080 LGIKTETPST VSTNASTPQS VSSVVHYLAM ALFQIEQGIE RRFLKAPLDA SDSGRSYKTV 1090 1100 1110 1120 1130 1140 LDRWRESLLS SASLSQVFLH LSTLDRSVIW SKSILNARCK ICRKKGDAEN MVLCDGCDRG 1150 1160 1170 1180 1190 1200 HHTYCVRPKL KTVPEGDWFC PECRPKQRSR RLSSRQRPSL ESDEDVEDSM GGEDDEVDGD 1210 1220 1230 1240 1250 1260 EEEGQSEEEE YEVEQDEDDS QEEEEVSLPK RGRPQVRLPV KTRGKLSSSF SSRGQQQEPG 1270 1280 1290 1300 1310 1320 RYPSRSQQST PKTTVSSKTG RSLRKINSAP PTETKSLRIA SRSTRHSHGP LQADVFVELL 1330 1340 1350 1360 1370 1380 SPRRKRRGRK SANNTPENSP NFPNFRVIAT KSSEQSRSVN IASKLSLQES ESKRRCRKRQ 1390 1400 1410 1420 1430 1440 SPEPSPVTLG RRSSGRQGGV HELSAFEQLV VELVRHDDSW PFLKLVSKIQ VPDYYDIIKK 1450 1460 1470 1480 1490 1500 PIALNIIREK VNKCEYKLAS EFIDDIELMF SNCFEYNPRN TSEAKAGTRL QAFFHIQAQK 1510 1520 LGLHVTPSNV DQVSTPPAAK KSRI « Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins." Poot R.A., Dellaire G., Huelsmann B.B., Grimaldi M.A., Corona D.F.V., Becker P.B., Bickmore W.A., Varga-Weisz P.D. EMBO J. 19:3377-3387(2000) [PubMed: 10880450] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[2]	"A family of chromatin remodeling factors related to Williams syndrome transcription factor." Bochar D.A., Savard J., Wang W., Lafleur D.W., Moore P., Cote J., Shiekhattar R. Proc. Natl. Acad. Sci. U.S.A. 97:1038-1043(2000) [PubMed: 10655480] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"A novel family of bromodomain genes." Jones M.H., Hamana N., Nezu J., Shimane M. Genomics 63:40-45(2000) [PubMed: 10662543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Testis.
[4]	"Human partial CDS from CD34+ stem cells." Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-540 (ISOFORM 1). Tissue: Umbilical cord blood.
[5]	The German cDNA consortium Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 746-1556 (ISOFORM 1). Tissue: Uterus.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1413 AND SER-1417, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-606, MASS SPECTROMETRY.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1413, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases
	AF213467 mRNA. Translation: AAF70601.1. AF221130 mRNA. Translation: AAF32366.1. AB032252 mRNA. Translation: BAA89209.1. AF161435 mRNA. Translation: AAF28995.1. Frameshift. AL050089 mRNA. Translation: CAB43261.1.
PIR	T08738.
RefSeq	NP_038476.2. NP_872589.1.
UniGene	Hs.509140
3D structure databases
HSSP	HSSP built from PDB template 1F62 based on UniProtKB Q9UIG0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NRL2.
PTM databases
PhosphoSite	Q9NRL2.
Genome annotation databases
Ensembl	ENSG00000198604. Homo sapiens. [Contig view]
GeneID	11177.
KEGG	hsa:11177.
Organism-specific databases
H-InvDB	HIX0011594.
HGNC	HGNC:960. BAZ1A.
HPA	HPA002730.
MIM	605680. gene.
PharmGKB	PA25270.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q9NRL2.
Gene expression databases
ArrayExpress	Q9NRL2.
CleanEx	HS_BAZ1A.
GermOnline	ENSG00000198604. Homo sapiens.
Family and domain databases
InterPro	IPR001487. Bromodomain. IPR004022. DDT. IPR013136. WSTF_Acf1_Cbp146. IPR001965. Znf_PHD. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Gene3D	G3DSA:1.20.920.10. Bromodomain. 1 hit. G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
Pfam	PF00439. Bromodomain. 1 hit. PF02791. DDT. 1 hit. PF00628. PHD. 1 hit. [Graphical view]
PRINTS	PR00503. BROMODOMAIN.
SMART	SM00297. BROMO. 1 hit. SM00571. DDT. 1 hit. SM00249. PHD. 1 hit. SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS00633. BROMODOMAIN_1. 1 hit. PS50014. BROMODOMAIN_2. 1 hit. PS50827. DDT. 1 hit. PS51136. WAC. 1 hit. PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 1 hit. [Graphical view]
ProDom	Q9NRL2. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Hide | Top

Entry information

Entry name

BAZ1A_HUMAN

Accession

Primary (citable) accession number: Q9NRL2
Secondary accession number(s): Q9NZ15

Q9Y3V3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	October 17, 2006
Last modified:	September 2, 2008
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Hide | Top

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents