Reviewed, UniProtKB/Swiss-Prot Q9NS68 (TNR19_HUMAN)

Names and origin

Protein names

Recommended name:
    Tumor necrosis factor receptor superfamily member 19
Alternative name(s):
    Toxicity and JNK inducer
    TRADE

Gene names

Name:	TNFRSF19
Synonyms:	TAJ, TROY
ORF Names:	UNQ1888/PRO4333

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.
Subunit structure	Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1.
Subcellular location	Membrane; Single-pass type I membrane proteinProbable.
Tissue specificity	Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.
Sequence similarities	Contains 3 TNFR-Cys repeats.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	JNK cascade Ref.1 Non-traceable author statement. Source: UniProtKB induction of apoptosis Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	tumor necrosis factor receptor activity Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TRAF1	Q13077	1	EBI-530381,EBI-359224
TRAF2	Q12933	1	EBI-530381,EBI-355744
TRAF5	O00463	1	EBI-530381,EBI-523498

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NS68-1)

Also known as: TAJ-alpha; TRADEalpha;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NS68-2)

Also known as: TRADEbeta;

The sequence of this isoform differs from the canonical sequence as follows:
     416-423: VRQRLGSL → EA

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 29	29
	Chain	30 – 423	394	Tumor necrosis factor receptor superfamily member 19
Regions
	Topological domain	30 – 170	141	Extracellular Potential
	Transmembrane	171 – 191	21	Potential
	Topological domain	192 – 423	232	Cytoplasmic Potential
	Repeat	33 – 72	40	TNFR-Cys 1
	Repeat	74 – 114	41	TNFR-Cys 2
	Repeat	116 – 149	34	TNFR-Cys 3
Amino acid modifications
	Glycosylation	105	1	N-linked (GlcNAc...) Potential
	Disulfide bond	34 ↔ 46		By similarity
	Disulfide bond	49 ↔ 62		By similarity
	Disulfide bond	52 ↔ 72		By similarity
	Disulfide bond	75 ↔ 89		By similarity
	Disulfide bond	92 ↔ 106		By similarity
	Disulfide bond	95 ↔ 114		By similarity
	Disulfide bond	117 ↔ 135		By similarity
	Disulfide bond	138 ↔ 149		By similarity
Natural variations
	Alternative sequence	416 – 423	8	VRQRLGSL → EA in isoform 2.
	Natural variant	31	1	S → T: dbSNP rs9550987.
	Natural variant	405	1	V → I: dbSNP rs3751362.
Experimental info
	Sequence conflict	74	1	T → A in AAF71828. Ref.1
	Sequence conflict	215 – 216	2	GS → ET in AAF71828. Ref.1
	Sequence conflict	221	1	F → L in AAK28396. Ref.3
	Sequence conflict	330	1	T → A in AAK28396. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (TAJ-alpha) (TRADEalpha) [UniParc]. Last modified October 1, 2000. Version 1. Checksum: B5891CEA9ED45361	FASTA	423	46,015
	10 20 30 40 50 60 MALKVLLEQE KTFFTLLVLL GYLSCKVTCE SGDCRQQEFR DRSGNCVPCN QCGPGMELSK 70 80 90 100 110 120 ECGFGYGEDA QCVTCRLHRF KEDWGFQKCK PCLDCAVVNR FQKANCSATS DAICGDCLPG 130 140 150 160 170 180 FYRKTKLVGF QDMECVPCGD PPPPYEPHCA SKVNLVKIAS TASSPRDTAL AAVICSALAT 190 200 210 220 230 240 VLLALLILCV IYCKRQFMEK KPSWSLRSQD IQYNGSELSC FDRPQLHEYA HRACCQCRRD 250 260 270 280 290 300 SVQTCGPVRL LPSMCCEEAC SPNPATLGCG VHSAASLQAR NAGPAGEMVP TFFGSLTQSI 310 320 330 340 350 360 CGEFSDAWPL MQNPMGGDNI SFCDSYPELT GEDIHSLNPE LESSTSLDSN SSQDLVGGAV 370 380 390 400 410 420 PVQSHSENFT AATDLSRYNN TLVESASTQD ALTMRSQLDQ ESGAVIHPAT QTSLQVRQRL GSL
	Isoform 2 (TRADEbeta) [UniParc]. Checksum: 3AA85D783F0835C4		417	45,305
	10 20 30 40 50 60 MALKVLLEQE KTFFTLLVLL GYLSCKVTCE SGDCRQQEFR DRSGNCVPCN QCGPGMELSK 70 80 90 100 110 120 ECGFGYGEDA QCVTCRLHRF KEDWGFQKCK PCLDCAVVNR FQKANCSATS DAICGDCLPG 130 140 150 160 170 180 FYRKTKLVGF QDMECVPCGD PPPPYEPHCA SKVNLVKIAS TASSPRDTAL AAVICSALAT 190 200 210 220 230 240 VLLALLILCV IYCKRQFMEK KPSWSLRSQD IQYNGSELSC FDRPQLHEYA HRACCQCRRD 250 260 270 280 290 300 SVQTCGPVRL LPSMCCEEAC SPNPATLGCG VHSAASLQAR NAGPAGEMVP TFFGSLTQSI 310 320 330 340 350 360 CGEFSDAWPL MQNPMGGDNI SFCDSYPELT GEDIHSLNPE LESSTSLDSN SSQDLVGGAV 370 380 390 400 410 PVQSHSENFT AATDLSRYNN TLVESASTQD ALTMRSQLDQ ESGAVIHPAT QTSLQEA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death." Eby M.T., Jasmin A., Kumar A., Sharma K., Chaudhary P.M. J. Biol. Chem. 275:15336-15342(2000) [PubMed: 10809768] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TRAF1; TRAF2; TRAF3 AND TRAF5. Tissue: Fetal spleen.
[2]	"TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles." Kojima T., Morikawa Y., Copeland N.G., Gilbert D.J., Jenkins N.A., Senba E., Kitamura T. J. Biol. Chem. 275:20742-20747(2000) [PubMed: 10764796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Glial tumor.
[3]	"TRADE, a novel TNF receptor family member associated with death signaling." Chaudhary D., Long A.J. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS THR-31 AND ILE-405.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[6]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 30-44.
[7]	"A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors." Park J.B., Yiu G., Kaneko S., Wang J., Chang J., He X.L., Garcia K.C., He Z. Neuron 45:345-351(2005) [PubMed: 15694321] [Abstract] Cited for: INTERACTION WITH LINGO1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF167555 mRNA. Translation: AAF71828.1. AB040434 mRNA. Translation: BAB03269.1. AF246998 mRNA. Translation: AAK28395.1. AF246999 mRNA. Translation: AAK28396.1. AY358888 mRNA. Translation: AAQ89247.1. BC047321 mRNA. Translation: AAH47321.1.
RefSeq	NP_061117.2. NP_683760.1.
UniGene	Hs.149168
3D structure databases
HSSP	HSSP built from PDB template 1JMA based on UniProtKB Q92956.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NS68.
Genome annotation databases
Ensembl	ENSG00000127863. Homo sapiens. [Contig view]
GeneID	55504.
KEGG	hsa:55504.
Organism-specific databases
H-InvDB	HIX0026539.
HGNC	HGNC:11915. TNFRSF19.
HPA	HPA010135.
MIM	606122. gene.
PharmGKB	PA36608.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q9NS68.
HOVERGEN	Q9NS68.
Gene expression databases
ArrayExpress	Q9NS68.
CleanEx	HS_TNFRSF19.
GermOnline	ENSG00000127863. Homo sapiens.
Family and domain databases
InterPro	IPR001368. TNFR_c6. [Graphical view]
Pfam	PF00020. TNFR_c6. 1 hit. [Graphical view]
SMART	SM00208. TNFR. 2 hits. [Graphical view]
PROSITE	PS00652. TNFR_NGFR_1. 2 hits. PS50050. TNFR_NGFR_2. 1 hit. [Graphical view]
ProDom	Q9NS68. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

TNR19_HUMAN

Accession

Primary (citable) accession number: Q9NS68
Secondary accession number(s): Q9BXZ9, Q9BY00, Q9NZV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	October 1, 2000
Last modified:	July 22, 2008
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)