Reviewed, UniProtKB/Swiss-Prot Q9NUJ1 (ABHDA_HUMAN)

Names and origin

Protein names

Recommended name:
    Abhydrolase domain-containing protein 10, mitochondrial
    EC=3.4.-.-

Gene names

Name:

ABHD10

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	MitochondrionPotential.
Sequence similarities	Belongs to the AB hydrolase superfamily.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide
Molecular function	Hydrolase Protease Serine protease
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from direct assay. Source: LIFEdb
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Transit peptide	1 – 52	52	Mitochondrion Potential
	Chain	53 – 306	254	Abhydrolase domain-containing protein 10, mitochondrial
Sites
	Active site	152	1	Charge relay system By similarity
	Active site	249	1	Charge relay system By similarity
	Active site	279	1	Charge relay system By similarity
Natural variations
	Natural variant	251	1	I → V: dbSNP rs17429033.

Sequences

	Sequence		Length	Mass (Da)
	Q9NUJ1-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: E41139D5C22A83FE	FASTA	306	33,933
	10 20 30 40 50 60 MAVARLAAVA AWVPCRSWGW AAVPFGPHRG LSVLLARIPQ RAPRWLPACR QKTSLSFLNR 70 80 90 100 110 120 PDLPNLAYKK LKGKSPGIIF IPGYLSYMNG TKALAIEEFC KSLGHACIRF DYSGVGSSDG 130 140 150 160 170 180 NSEESTLGKW RKDVLSIIDD LADGPQILVG SSLGGWLMLH AAIARPEKVV ALIGVATAAD 190 200 210 220 230 240 TLVTKFNQLP VELKKEVEMK GVWSMPSKYS EEGVYNVQYS FIKEAEHHCL LHSPIPVNCP 250 260 270 280 290 300 IRLLHGMKDD IVPWHTSMQV ADRVLSTDVD VILRKHSDHR MREKADIQLL VYTIDDLIDK LSTIVN

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[3]	The German cDNA consortium Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 73-306. Tissue: Melanoma.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK002204 mRNA. Translation: BAA92133.1. BC014516 mRNA. Translation: AAH14516.1. AL713726 mRNA. Translation: CAD28516.2.
RefSeq	NP_060864.1.
UniGene	Hs.477115
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9NUJ1.
Proteomic databases
PeptideAtlas	Q9NUJ1.
Genome annotation databases
Ensembl	ENSG00000144827. Homo sapiens. [Contig view]
GeneID	55347.
KEGG	hsa:55347.
Organism-specific databases
HGNC	HGNC:25656. ABHD10.
PharmGKB	PA134978569.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q9NUJ1.
Gene expression databases
ArrayExpress	Q9NUJ1.
CleanEx	HS_ABHD10.
Family and domain databases
InterPro	IPR003089. AB_hydrolase. IPR000073. AB_hydrolase_1. [Graphical view]
Pfam	PF00561. Abhydrolase_1. 1 hit. [Graphical view]
PRINTS	PR00111. ABHYDROLASE.
ProDom	Q9NUJ1. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ABHDA_HUMAN

Accession

Primary (citable) accession number: Q9NUJ1
Secondary accession number(s): Q8TCF9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	October 1, 2000
Last modified:	July 22, 2008
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)