Reviewed, UniProtKB/Swiss-Prot Q9NUQ8 (ABCF3_HUMAN)

Names and origin

Protein names

Recommended name:
    ATP-binding cassette sub-family F member 3

Gene names

Name:

ABCF3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	709 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities	Belongs to the ABC transporter family. EF3 subfamily. Contains 2 ABC transporter domains.
Caution	Lacks transmembrane domains and is probably not involved in transport.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NUQ8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NUQ8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     69-74: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 709	709	ATP-binding cassette sub-family F member 3
Regions
	Domain	178 – 424	247	ABC transporter 1
	Domain	492 – 707	216	ABC transporter 2
	Nucleotide binding	210 – 217	8	ATP 1 Potential
	Nucleotide binding	525 – 532	8	ATP 2 Potential
Natural variations
	Alternative sequence	69 – 74	6	Missing in isoform 2.
	Natural variant	503	1	P → L: dbSNP rs11706273.
	Natural variant	510	1	R → H: dbSNP rs9811715.
Experimental info
	Sequence conflict	231	1	P → S in BAC03881. Ref.1
	Sequence conflict	289	1	A → G in BAB14989. Ref.1
	Sequence conflict	468	1	K → R in BAA92063. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: E7E0FDB6426F3F60	FASTA	709	79,745
	10 20 30 40 50 60 MATCAEILRS EFPEIDGQVF DYVTGVLHSG SADFESVDDL VEAVGELLQE VSGDSKDDAG 70 80 90 100 110 120 IRAVCQRMYN TLRLAEPQSQ GNSQVLLDAP IQLSKITENY DCGTKLPGLL KREQSSTVNA 130 140 150 160 170 180 KKLEKAEARL KAKQEKRSEK DTLKTSNPLV LEEASASQAG SRKESRLESS GKNKSYDVRI 190 200 210 220 230 240 ENFDVSFGDR VLLAGADVNL AWGRRYGLVG RNGLGKTTLL KMLATRSLRV PAHISLLHVE 250 260 270 280 290 300 QEVAGDDTPA LQSVLESDSV REDLLRRERE LTAQIAAGRA EGSEAAELAE IYAKLEEIEA 310 320 330 340 350 360 DKAPARASVI LAGLGFTPKM QQQPTREFSG GWRMRLALAR ALFARPDLLL LDEPTNMLDV 370 380 390 400 410 420 RAILWLENYL QTWPSTILVV SHDRNFLNAI ATDIIHLHSQ RLDGYRGDFE TFIKSKQERL 430 440 450 460 470 480 LNQQREYEAQ QQYRQHIQVF IDRFRYNANR ASQVQSKLKM LEKLPELKPV DKESEVVMKF 490 500 510 520 530 540 PDGFEKFSPP ILQLDEVDFY YDPKHVIFSR LSVSADLESR ICVVGENGAG KSTMLKLLLG 550 560 570 580 590 600 DLAPVRGIRH AHRNLKIGYF SQHHVEQLDL NVSAVELLAR KFPGRPEEEY RHQLGRYGIS 610 620 630 640 650 660 GELAMRPLAS LSGGQKSRVA FAQMTMPCPN FYILDEPTNH LDMETIEALG RALNNFRGGV 670 680 690 700 ILVSHDERFI RLVCRELWVC EGGGVTRVEG GFDQYRALLQ EQFRREGFL
	Isoform 2 [UniParc]. Checksum: F952B10FD525CEB7		703	78,984
	10 20 30 40 50 60 MATCAEILRS EFPEIDGQVF DYVTGVLHSG SADFESVDDL VEAVGELLQE VSGDSKDDAG 70 80 90 100 110 120 IRAVCQRMAE PQSQGNSQVL LDAPIQLSKI TENYDCGTKL PGLLKREQSS TVNAKKLEKA 130 140 150 160 170 180 EARLKAKQEK RSEKDTLKTS NPLVLEEASA SQAGSRKESR LESSGKNKSY DVRIENFDVS 190 200 210 220 230 240 FGDRVLLAGA DVNLAWGRRY GLVGRNGLGK TTLLKMLATR SLRVPAHISL LHVEQEVAGD 250 260 270 280 290 300 DTPALQSVLE SDSVREDLLR RERELTAQIA AGRAEGSEAA ELAEIYAKLE EIEADKAPAR 310 320 330 340 350 360 ASVILAGLGF TPKMQQQPTR EFSGGWRMRL ALARALFARP DLLLLDEPTN MLDVRAILWL 370 380 390 400 410 420 ENYLQTWPST ILVVSHDRNF LNAIATDIIH LHSQRLDGYR GDFETFIKSK QERLLNQQRE 430 440 450 460 470 480 YEAQQQYRQH IQVFIDRFRY NANRASQVQS KLKMLEKLPE LKPVDKESEV VMKFPDGFEK 490 500 510 520 530 540 FSPPILQLDE VDFYYDPKHV IFSRLSVSAD LESRICVVGE NGAGKSTMLK LLLGDLAPVR 550 560 570 580 590 600 GIRHAHRNLK IGYFSQHHVE QLDLNVSAVE LLARKFPGRP EEEYRHQLGR YGISGELAMR 610 620 630 640 650 660 PLASLSGGQK SRVAFAQMTM PCPNFYILDE PTNHLDMETI EALGRALNNF RGGVILVSHD 670 680 690 700 ERFIRLVCRE LWVCEGGGVT RVEGGFDQYR ALLQEQFRRE GFL

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Placenta and Vascular smooth muscle.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Cervix, Muscle and Skin.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK002060 mRNA. Translation: BAA92063.1. AK024758 mRNA. Translation: BAB14989.1. Different initiation. AK092415 mRNA. Translation: BAC03881.1. BC009253 mRNA. Translation: AAH09253.1. BC051754 mRNA. Translation: AAH51754.1. BC051884 mRNA. Translation: AAH51884.2.
RefSeq	NP_060828.2.
UniGene	Hs.361323
3D structure databases
HSSP	HSSP built from PDB template 1F2T based on UniProtKB P58301.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000161204. Homo sapiens. [Contig view]
GeneID	55324.
KEGG	hsa:55324.
Organism-specific databases
HGNC	HGNC:72. ABCF3.
PharmGKB	PA24407.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q9NUQ8.
HOVERGEN	Q9NUQ8.
Gene expression databases
ArrayExpress	Q9NUQ8.
CleanEx	HS_ABCF3.
GermOnline	ENSG00000161204. Homo sapiens.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase_core. IPR003439. ABC_transporter-like. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
ProDom	PD000006. ABC_transporter. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ABCF3_HUMAN

Accession

Primary (citable) accession number: Q9NUQ8
Secondary accession number(s): Q86UA2 , Q8NAN1, Q96GS8, Q9H7A8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	July 22, 2008
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)