Reviewed, UniProtKB/Swiss-Prot Q9NVR5 (CN104_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C14orf104

Gene names

Name:

C14orf104

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NVR5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NVR5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     113-160: Missing.

Notes: May be due to exon skipping.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 328	328	Uncharacterized protein C14orf104
Natural variations
	Alternative sequence	113 – 160	48	Missing in isoform 2.
	Natural variant	259	1	D → G: dbSNP rs9989177.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 87875CE2A89AF663	FASTA	328	36,943
	10 20 30 40 50 60 MGGPGTKSGE PLCPPLLCNQ DKETLTLLIQ VPRIQPQSLQ GDLNPLWYKL RFSAQDLVYS 70 80 90 100 110 120 FFLQFAPENK LSTTEPVISI SSNNAVIELA KSPESHGHWR EWYYGVNNDS LEERLFVNEE 130 140 150 160 170 180 NVNEFLEEVL SSPFKQSMSL TPPLIEVLQV TDNKIQINAK LQECSNSDQL QGKEERVNEE 190 200 210 220 230 240 SHLTEKEYIE HCNTPTTDSD SSIAVKALQI DSFGLVTCFQ QESLDVSQMI LGKSQQPESK 250 260 270 280 290 300 MQSEFIKEKS ATCSNEEKDN LNESVITEEK ETDGDHLSSL LNKTTVHNIP GFDSIKETNM 310 320 QDGSVQVIKD HVTNCAFSFQ NSLLYDLD
	Isoform 2 [UniParc]. Checksum: 4A22CCA331F50DA6		280	31,429
	10 20 30 40 50 60 MGGPGTKSGE PLCPPLLCNQ DKETLTLLIQ VPRIQPQSLQ GDLNPLWYKL RFSAQDLVYS 70 80 90 100 110 120 FFLQFAPENK LSTTEPVISI SSNNAVIELA KSPESHGHWR EWYYGVNNDS LELQECSNSD 130 140 150 160 170 180 QLQGKEERVN EESHLTEKEY IEHCNTPTTD SDSSIAVKAL QIDSFGLVTC FQQESLDVSQ 190 200 210 220 230 240 MILGKSQQPE SKMQSEFIKE KSATCSNEEK DNLNESVITE EKETDGDHLS SLLNKTTVHN 250 260 270 280 IPGFDSIKET NMQDGSVQVI KDHVTNCAFS FQNSLLYDLD

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Neuroblastoma.
[3]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Bone marrow and Colon.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK001425 mRNA. Translation: BAA91684.1. BX248264 mRNA. Translation: CAD62592.1. Different initiation. AL139099 Genomic DNA. No translation available. BC013322 mRNA. Translation: AAH13322.1. BC011400 mRNA. Translation: AAH11400.1.
UniGene	Hs.231761
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000165506. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:20188. C14orf104.
HPA	HPA002894. HPA004113.
PharmGKB	PA134910310.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q9NVR5.
HOVERGEN	Q9NVR5.
Gene expression databases
ArrayExpress	Q9NVR5.
CleanEx	HS_C14orf104.
GermOnline	ENSG00000165506. Homo sapiens.
Family and domain databases
ProDom	Q9NVR5. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	Q9NVR5.
ProtoNet	Search...

Entry information

Entry name

CN104_HUMAN

Accession

Primary (citable) accession number: Q9NVR5
Secondary accession number(s): Q86TY8, Q969Z5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	October 1, 2000
Last modified:	July 22, 2008
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)