Reviewed, UniProtKB/Swiss-Prot Q9NX78 (CN101_HUMAN)

Names and origin

Protein names

Recommended name:
    Transmembrane protein C14orf101

Gene names

Name:

C14orf101

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	707 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane proteinPotential.
Sequence caution	The sequence BC045556 differs from that shown. Reason: Frameshift at position 212.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane
PTM	Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NX78-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NX78-2)

The sequence of this isoform differs from the canonical sequence as follows:
     287-707: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 707	707	Transmembrane protein C14orf101
Regions
	Transmembrane	28 – 48	21	Potential
	Transmembrane	71 – 91	21	Potential
	Transmembrane	94 – 114	21	Potential
	Transmembrane	141 – 161	21	Potential
	Transmembrane	189 – 209	21	Potential
	Transmembrane	222 – 242	21	Potential
	Transmembrane	318 – 338	21	Potential
	Transmembrane	356 – 376	21	Potential
Amino acid modifications
	Modified residue	131	1	Phosphoserine
	Modified residue	133	1	Phosphoserine
Natural variations
	Alternative sequence	287 – 707	421	Missing in isoform 2.
Experimental info
	Sequence conflict	245	1	A → S Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 24, 2003. Version 2. Checksum: 1FC83255C01C36FC	FASTA	707	79,528
	10 20 30 40 50 60 MSHHGDGRGQ AQGRAVRVGL RRSGGIRGGV AVFAAVAAVF TFTLPPSVPG GDSGELITAA 70 80 90 100 110 120 HELGVAHPPG YPLFTLVAKL AITLFPFGSI AYRVNLLCGL FGAVAASLLF FTVFRLSGSS 130 140 150 160 170 180 AGGILAAGVF SFSRLTWQWS IAAEVFSLNN LFVGLLMALT VHFEEAATAK ERSKVAKIGA 190 200 210 220 230 240 FCCGLSLCNQ HTIILYVLCI IPWILFQLLK KKELSLGSLL KLSLYFSAGL LPYVHLPISS 250 260 270 280 290 300 YLNHARWTWG DQTTLQGFLT HFLREEYGTF SLAKSEIGSS MSEILLSQVT NMRTELSFNI 310 320 330 340 350 360 QALAVCANIC LATKDRQNPS LVWLFTGMFC IYSLVFAWRA NLDISKPLFM GVVERFWMQS 370 380 390 400 410 420 NAVVAVLAGI GLAAVVSETN RVLNSNGLQC LEWLSATLFV VYQIYSNYSV CDQRTNYVID 430 440 450 460 470 480 KFAKNLLTSM PHDAIILLRG DLPGNSLRYM HYCEGLRPDI SLVDQEMMTY EWYLPKMAKH 490 500 510 520 530 540 LPGVNFPGNR WNPVEGILPS GMVTFNLYHF LEVNKQKETF VCIGIHEGDP TWKKNYSLWP 550 560 570 580 590 600 WGSCDKLVPL EIVFNPEEWI KLTKSIYNWT EEYGRFDPSS WESVANEEMW QARMKTPFFI 610 620 630 640 650 660 FNLAETAHMP SKVKAQLYAQ AYDLYKEIVY LQKEHPVNWH KNYAIACERM LRLQARDADP 670 680 690 700 EVLLSETIRH FRLYSQKAPN DPQQADILGA LKHLRKELQS LRNRKNV
	Isoform 2 [UniParc]. Checksum: 9FF3A43DA8490E4E		286	30,742
	10 20 30 40 50 60 MSHHGDGRGQ AQGRAVRVGL RRSGGIRGGV AVFAAVAAVF TFTLPPSVPG GDSGELITAA 70 80 90 100 110 120 HELGVAHPPG YPLFTLVAKL AITLFPFGSI AYRVNLLCGL FGAVAASLLF FTVFRLSGSS 130 140 150 160 170 180 AGGILAAGVF SFSRLTWQWS IAAEVFSLNN LFVGLLMALT VHFEEAATAK ERSKVAKIGA 190 200 210 220 230 240 FCCGLSLCNQ HTIILYVLCI IPWILFQLLK KKELSLGSLL KLSLYFSAGL LPYVHLPISS 250 260 270 280 YLNHARWTWG DQTTLQGFLT HFLREEYGTF SLAKSEIGSS MSEILL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 161-707 (ISOFORM 1). Tissue: Ileal mucosa.
[3]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131 AND SER-133, MASS SPECTROMETRY. Tissue: Epithelium.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC045556 mRNA. No translation available. AK000399 mRNA. Translation: BAA91139.1. Different initiation.
UniGene	Hs.497253
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000070269. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:20185. C14orf101.
HPA	HPA003502.
PharmGKB	PA134894829.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q9NX78.
HOVERGEN	Q9NX78.
Gene expression databases
ArrayExpress	Q9NX78.
CleanEx	HS_C14orf101.
GermOnline	ENSG00000070269. Homo sapiens.
Family and domain databases
ProDom	Q9NX78. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

CN101_HUMAN

Accession

Primary (citable) accession number: Q9NX78
Secondary accession number(s): Q86XE1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	October 24, 2003
Last modified:	July 22, 2008
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)