Reviewed, UniProtKB/Swiss-Prot Q9NZP6 (CO002_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein C15orf2

Gene names

Name:

C15orf2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1156 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be involved in spermatogenesis.
Tissue specificity	Testis-specific in adults.

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis
Coding sequence diversity	Polymorphism
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	spermatogenesis Ref.1 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 1156	1156	Protein C15orf2
Regions
	Compositional bias	285 – 536	252	Pro-rich
Natural variations
	Natural variant	37	1	R → Q in a colorectal cancer sample; somatic mutation.
	Natural variant	114	1	V → I in a colorectal cancer sample; somatic mutation.
	Natural variant	212	1	V → A: dbSNP rs3784246.
	Natural variant	253	1	G → R: dbSNP rs1563102.
	Natural variant	282	1	N → S: dbSNP rs7165533.
	Natural variant	406	1	Q → E: dbSNP rs3742950.

Sequences

	Sequence		Length	Mass (Da)
	Q9NZP6-1 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: EB8ABE1B1C932CE6	FASTA	1,156	120,954
	10 20 30 40 50 60 MGNLLSKFRP GCRRRPLPGP GRGAPAPLSR DASPPGRAHS VPTPRPFRGL FRRNARRRPS 70 80 90 100 110 120 AASIFVAPKR PCPLPRAAAA PLGVLPAVGW GLAIRKTPML PARNPPRFGH PSSVRIPPPS 130 140 150 160 170 180 RMFTLLLPSP REPAVKARKP IPATLLEETE VWAQEGPRRV KKDEDPVQIE GEDDEKRTPL 190 200 210 220 230 240 SSGEASSTSR SQGTQGDVAS FRCSPGPLEG NVYHKFSENS MSEKAQASPA SSCLEGPAMP 250 260 270 280 290 300 STHSQAGCAR HLGKPDPDAT APPEPAVGCS LLQQKLAAEV LNEEPPPSSL GLPIPLMSGK 310 320 330 340 350 360 RMPDEKPFCI PPRSAAPPRA ARNRPCKRKM SIPLLLPLPP SLPLLWDRGE LPPPAKLPCL 370 380 390 400 410 420 SVEGDLHTLE KSPEYKRNSR ILEDKTETMT NSSITQPAPS FSQPVQTTDS LPLTTYTSQV 430 440 450 460 470 480 SAPLPIPDLA DLATGPLILP IPPLSTTPKM DEKIAFTIPN SPLALPADLV PILGDQSNEK 490 500 510 520 530 540 GGSYNSVVGA APLTSDPPTP PSSTPSFKPP VTRESPISMC VDSPPPLSFL TLLPVPSTGT 550 560 570 580 590 600 SVITSKPMNS TSVISTVTTN ASAHLTSQTA VDPEVVNMDT TAPSQVVIFT SSLSSRVSSL 610 620 630 640 650 660 PNSQIHCSAE QRHPGKTSVY TSPLPFIFHN TTPSFNQLFG KEATPQPKFE APDGQPQKAS 670 680 690 700 710 720 LPSACVFLSL PIIPPPDTST LVNSASTASS SKPPIETNAM HTTPPSKAVI LQSASVSKKY 730 740 750 760 770 780 LPFYLGLPGS GNTQPSGNTA SVQGSTSLPA QSVRAPATAS NHPLNPGATP QPKFGAPDGP 790 800 810 820 830 840 QQKTSLPSAH DFLSLPIMVP PDTSTLVSSA SAASLSKPAI DTSDMNTTPP SKTVILQSTF 850 860 870 880 890 900 VSRKEEYIRF YMGLPGSGNT LHSDSIASAQ VSTSFPAQAD RRPTTTSSHP LNTGSISHST 910 920 930 940 950 960 LGATDGQQKS DSSFILGNPA TPAPVIGLTS PSVQPLSGSI IPPGFAELTS PYTALGTPVN 970 980 990 1000 1010 1020 AEPVEGHNAS AFPNGTAKTS GFRIATGMPG TGDSTLLVGN TIPGPQVIMG PGTPMDGGSI 1030 1040 1050 1060 1070 1080 GFSMSAPGPS STSGELNIGQ GQSGTPSTTS VFPFGQAAWD PTGHSMAAAP QGASNIPVFG 1090 1100 1110 1120 1130 1140 YTSAAAYIPG LDPPTQNSCS GMGGDGTRSI VGGPCVPAFQ QCILQHTWTE RKFYTSSTHY 1150 YGQETYVRRH VCFQLP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a testis-specific gene (c15orf2) in the Prader-Willi syndrome region on chromosome 15." Faerber C., Gross S., Neesen J., Buiting K., Horsthemke B. Genomics 65:174-183(2000) [PubMed: 10783265] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], POSSIBLE FUNCTION, TISSUE SPECIFICITY, VARIANT ARG-253.
[2]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed: 16572171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLN-37 AND ILE-114.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF179681 Genomic DNA. Translation: AAF72107.1. AC100720 Genomic DNA. No translation available.
RefSeq	NP_061831.2.
UniGene	Hs.649663
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000185823. Homo sapiens. [Contig view]
GeneID	23742.
KEGG	hsa:23742.
NMPDR	fig|9606.3.peg.10362.
Organism-specific databases
HGNC	HGNC:1190. C15orf2.
MIM	610922. gene.
PharmGKB	PA25519.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	Q9NZP6.
HOVERGEN	Q9NZP6.
Gene expression databases
ArrayExpress	Q9NZP6.
CleanEx	HS_C15orf2.
GermOnline	ENSG00000185823. Homo sapiens.
Family and domain databases
ProDom	Q9NZP6. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	Q9NZP6.
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

CO002_HUMAN

Accession

Primary (citable) accession number: Q9NZP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	May 15, 2007
Last modified:	July 22, 2008
This is version 31 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)