Reviewed, UniProtKB/Swiss-Prot Q9PLH5 (SYA_CHLMU)

Names and origin

Protein names

Recommended name:
    Alanyl-tRNA synthetase
    EC=6.1.1.7
Alternative name(s):
    Alanine--tRNA ligase
      Short name=AlaRS

Gene names

Name:	alaS
Ordered Locus Names:	TC_0125

Organism

Chlamydia muridarum [Complete proteome] [HAMAP]

Taxonomic identifier

83560 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	875 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP alanine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 875	875	Alanyl-tRNA synthetase

Sequences

	Sequence		Length	Mass (Da)
	Q9PLH5-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: A75F8977A23DC41D	FASTA	875	98,186
	10 20 30 40 50 60 MLSNTLRSNF LKFYTNRNHT PVASSPVFPY NDPSILFTNA GMNQFKNIFL GKEQTSYTRA 70 80 90 100 110 120 TTSQKCIRAG GKHNDLENVG HTSRHLTFFE MLGNFSFGDY FKQDAISFAW EVSLSVFNFD 130 140 150 160 170 180 PDFIYATVHE KDDEAFALWE KYLPTNRIFR LTDKDNFWSM ADTGPCGFCS ELLFDRGEKF 190 200 210 220 230 240 GKATSPLEDA DGERFLEYWN LVFMEFNRTS DGTLLALQKK CVDTGAGLER LVSLLSETDT 250 260 270 280 290 300 VFEADVLRHL IAKVENLSEI TYSPTESKGS AFRVIADHVR SLSFAITDGL LPGNTERGYV 310 320 330 340 350 360 LRKILRRAVN YGKRLGFHRP FLAEIVPSLI ETMGEAYPEL QAAETQIQEV LTTEEEHFFK 370 380 390 400 410 420 TLQRGGNLLH QVLKSSASLS KISGEDAFKL KDTYGLPIDE IALLAKDHNY TVDMDTFRKL 430 440 450 460 470 480 EMEAKERSRK NTVKNKNDSD SIFQDVDPTN TSEFVGYDML SCDTFIEGIV KYNEIASTLE 490 500 510 520 530 540 EGEEGAIILR TTPFYAEKGG QVGDSGEIFC ESGTFLVSHT TTPKAGLIAH HGKLSQGSLQ 550 560 570 580 590 600 TTMAVTAQVN QNLRKKIANN HTGCHLLHKA LEVSLGEHIR QAGSYVDSQK IRLDFSHNKA 610 620 630 640 650 660 LSPEELLTIE TLVNEKIREN VPVTIREALY SDVMNSSEIK QFFGDKYGDI VRVVSAGFSH 670 680 690 700 710 720 ELCGGTHARA TGDIGYFRIT KEHAVSTGIR RIEATTGEDA ENIARGQDTD LNEIATIIQS 730 740 750 760 770 780 PKDQLLVKLR NVMEEKKDLA KQLANLENQL VQQQVKSLLT SCDKVNETSY LVYHLTEEEG 790 800 810 820 830 840 QRIQHYANTL HKEVPAKFIS LWVTEKNDRY IVLVRVSDDL VKQGIDAQAL LEELLAPYGG 850 860 870 RCGGKAVSAQ GSSKELPQIE VLNTILRQWI STRLA

References

[1]

"Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae AR39." Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O., Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S., Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J., Gwinn M.L. , Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G., Salzberg S.L., Eisen J.A., Fraser C.M. Nucleic Acids Res. 28:1397-1406(2000) [PubMed: 10684935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MoPn / Nigg.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE002160 Genomic DNA. Translation: AAF39003.1.
PIR	H81739.
RefSeq	NP_296508.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1245659.
GenomeReviews	Gene locus TC_0125 in contig AE002160_GR.
KEGG	cmu:TC0125.
TIGR	TC_0125.
Phylogenomic databases
HOGENOM	Q9PLH5.
Enzyme and pathway databases
BioCyc	CMUR243161:TC_0125-MON.
Family and domain databases
HAMAP	MF_00036. [Tree]
InterPro	IPR002318. Ala-tRNA-synth_IIc. IPR003156. Pesterase_DHHA1. IPR012947. tRNA_SAD. [Graphical view]
Pfam	PF02272. DHHA1. 1 hit. PF01411. tRNA-synt_2c. 1 hit. PF07973. tRNA_SAD. 1 hit. [Graphical view]
PRINTS	PR00980. TRNASYNTHALA.
TIGRFAMs	TIGR00344. alaS. 1 hit.
PROSITE	PS50860. AA_TRNA_LIGASE_II_ALA. 1 hit. [Graphical view]
ProDom	Q9PLH5. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

SYA_CHLMU

Accession

Primary (citable) accession number: Q9PLH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	October 1, 2000
Last modified:	July 22, 2008
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)