Reviewed, UniProtKB/Swiss-Prot Q9SRW9 (CSLD5_ARATH)

Names and origin

Protein names

Recommended name:
    Cellulose synthase-like protein D5
      Short name=AtCslD5
    EC=2.4.1.-

Gene names

Name:	CSLD5
Ordered Locus Names:	At1g02730
ORF Names:	F22D16.26

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	1181 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Involved in stem and root growth. Possesses xylan and homogalacturonan synthase activity.
Subcellular location	Golgi apparatus membrane; Multi-pass membrane proteinProbable.
Tissue specificity	Expressed in vascular tissues.
Developmental stage	Expressed at its highest level between 21 and 25 days, during the inflorescence stem elongation phase.
Miscellaneous	Plants lacking CSLD5 (T-DNA tagging) display significant reduction of root and stem growth, xylan reduction in stem and increased susceptibility to the cellulose synthase inhibitor isoxaben.
Sequence similarities	Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like D subfamily.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Golgi apparatus Membrane
Domain	Coiled coil Transmembrane
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW cellulose biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cellulose synthase (UDP-forming) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1181	1181	Cellulose synthase-like protein D5		PRO_0000319350
Regions
	Transmembrane	312 – 332	21	Potential
	Transmembrane	343 – 363	21	Potential
	Transmembrane	966 – 986	21	Potential
	Transmembrane	991 – 1011	21	Potential
	Transmembrane	1038 – 1058	21	Potential
	Transmembrane	1082 – 1102	21	Potential
	Transmembrane	1116 – 1136	21	Potential
	Transmembrane	1146 – 1166	21	Potential
	Coiled coil	497 – 542	46	Potential
Sites
	Active site	443	1	Potential
	Active site	884	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9SRW9-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: B7D0C72FF5D20A5D	FASTA	1,181	132,587
	10 20 30 40 50 60 MVKSAASQSP SPVTITVTPC KGSGDRSLGL TSPIPRASVI TNQNSPLSSR ATRRTSISSG 70 80 90 100 110 120 NRRSNGDEGR YCSMSVEDLT AETTNSECVL SYTVHIPPTP DHQTVFASQE SEEDEMLKGN 130 140 150 160 170 180 SNQKSFLSGT IFTGGFKSVT RGHVIDCSMD RADPEKKSGQ ICWLKGCDEK VVHGRCECGF 190 200 210 220 230 240 RICRDCYFDC ITSGGGNCPG CKEPYRDIND DPETEEEDEE DEAKPLPQMG ESKLDKRLSV 250 260 270 280 290 300 VKSFKAQNQA GDFDHTRWLF ETKGTYGYGN AVWPKDGYGI GSGGGGNGYE TPPEFGERSK 310 320 330 340 350 360 RPLTRKVSVS AAIISPYRLL IALRLVALGL FLTWRVRHPN REAMWLWGMS TTCELWFALS 370 380 390 400 410 420 WLLDQLPKLC PVNRLTDLGV LKERFESPNL RNPKGRSDLP GIDVFVSTAD PEKEPPLVTA 430 440 450 460 470 480 NTILSILAVD YPVEKLACYL SDDGGALLTF EALAQTASFA STWVPFCRKH NIEPRNPEAY 490 500 510 520 530 540 FGQKRNFLKN KVRLDFVRER RRVKREYDEF KVRINSLPEA IRRRSDAYNV HEELRAKKKQ 550 560 570 580 590 600 MEMMMGNNPQ ETVIVPKATW MSDGSHWPGT WSSGETDNSR GDHAGIIQAM LAPPNAEPVY 610 620 630 640 650 660 GAEADAENLI DTTDVDIRLP MLVYVSREKR PGYDHNKKAG AMNALVRTSA IMSNGPFILN 670 680 690 700 710 720 LDCDHYIYNS MALREGMCFM LDRGGDRICY VQFPQRFEGI DPNDRYANHN TVFFDVSMRA 730 740 750 760 770 780 LDGLQGPMYV GTGCIFRRTA LYGFSPPRAT EHHGWLGRRK VKISLRRPKA MMKKDDEVSL 790 800 810 820 830 840 PINGEYNEEE NDDGDIESLL LPKRFGNSNS FVASIPVAEY QGRLIQDLQG KGKNSRPAGS 850 860 870 880 890 900 LAVPREPLDA ATVAEAISVI SCFYEDKTEW GKRVGWIYGS VTEDVVTGYR MHNRGWRSIY 910 920 930 940 950 960 CVTKRDAFRG TAPINLTDRL HQVLRWATGS VEIFFSRNNA IFATRRMKFL QRVAYFNVGM 970 980 990 1000 1010 1020 YPFTSLFLIV YCILPAISLF SGQFIVQSLD ITFLIYLLSI TLTLCMLSLL EIKWSGITLH 1030 1040 1050 1060 1070 1080 EWWRNEQFWV IGGTSAHPAA VLQGLLKVIA GVDISFTLTS KSSAPEDGDD EFADLYVVKW 1090 1100 1110 1120 1130 1140 SFLMVPPLTI MMVNMIAIAV GLARTLYSPF PQWSKLVGGV FFSFWVLCHL YPFAKGLMGR 1150 1160 1170 1180 RGRVPTIVFV WSGLLSIIVS LLWVYINPPS GKQDYMQFQF P

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"The cellulose synthase superfamily." Richmond T.A., Somerville C.R. Plant Physiol. 124:495-498(2000) [PubMed: 11027699] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
[3]	"Disruption of ATCSLD5 results in reduced growth, reduced xylan and homogalacturonan synthase activity and altered xylan occurrence in Arabidopsis." Bernal A.J., Jensen J.K., Harholt J., Soerensen S., Moller I., Blaukopf C., Johansen B., de Lotto R., Pauly M., Scheller H.V., Willats W.G.T. Plant J. 52:791-802(2007) [PubMed: 17892446] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC009525 Genomic DNA. Translation: AAF02892.1.
PIR	D86157.
RefSeq	NP_171773.1.
UniGene	At.42583
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	839467.
GenomeReviews	Gene locus AT1G02730 in contig CT485782_GR.
KEGG	ath:AT1G02730.
NMPDR	fig|3702.1.peg.395.
Organism-specific databases
TAIR	At1g02730.
Family and domain databases
InterPro	IPR005150. Cellulose_synth. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Gene3D	G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
Pfam	PF03552. Cellulose_synt. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CSLD5_ARATH

Accession

Primary (citable) accession number: Q9SRW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 1, 2000
Last modified:	November 25, 2008
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)