Reviewed, UniProtKB/Swiss-Prot Q9TUI5 (MT4_CANFA)

Names and origin

Protein names

Recommended name:
    Metallothionein-4
      Short name=MT-4
Alternative name(s):
    Metallothionein-IV
      Short name=MT-IV

Gene names

Name:

MT4

Organism

Canis familiaris (Dog)

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis

Protein attributes

Sequence length	62 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia By similarity.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Ligand	Copper Metal-binding Metal-thiolate cluster Zinc
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 62	62	Metallothionein-4
Sites
	Metal binding	6	1	Cluster B By similarity
	Metal binding	8	1	Cluster B By similarity
	Metal binding	14	1	Cluster B By similarity
	Metal binding	16	1	Cluster B By similarity
	Metal binding	20	1	Cluster B By similarity
	Metal binding	22	1	Cluster B By similarity
	Metal binding	25	1	Cluster B By similarity
	Metal binding	27	1	Cluster B By similarity
	Metal binding	30	1	Cluster B By similarity
	Metal binding	34	1	Cluster A By similarity
	Metal binding	35	1	Cluster A By similarity
	Metal binding	37	1	Cluster A By similarity
	Metal binding	38	1	Cluster A By similarity
	Metal binding	42	1	Cluster A By similarity
	Metal binding	45	1	Cluster A By similarity
	Metal binding	49	1	Cluster A By similarity
	Metal binding	51	1	Cluster A By similarity
	Metal binding	58	1	Cluster A By similarity
	Metal binding	60	1	Cluster A By similarity
	Metal binding	61	1	Cluster A By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9TUI5-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 2858DA6D17AA3DC9	FASTA	62	6,249
	10 20 30 40 50 60 MDPGECTCMS GGICICGDNC KCTTCNCKTC RKSCCPCCPP GCAKCAQGCI CKGGSDKCSC CA

References

[1]	"Molecular cloning and expression of metallothionein-IV." Kobayashi K., Morita T., Shimada A. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Beagle. Tissue: Tongue.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB028041 mRNA. Translation: BAA87326.1.
RefSeq	NP_001003150.1.
UniGene	Cfa.3632
3D structure databases
HSSP	HSSP built from PDB template 1MRB based on UniProtKB P18055.
ModBase	Search...
Genome annotation databases
Ensembl	ENSCAFG00000009118. Canis familiaris. [Contig view]
GeneID	403769.
KEGG	cfa:403769.
Phylogenomic databases
HOVERGEN	Q9TUI5.
Family and domain databases
InterPro	IPR001450. 4Fe4S_Fe_S_bd. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00353. 4FE4SFRDOXIN. PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProDom	Q9TUI5. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

MT4_CANFA

Accession

Primary (citable) accession number: Q9TUI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	May 1, 2000
Last modified:	July 22, 2008
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)