Reviewed, UniProtKB/Swiss-Prot Q9UHA3 (RLP24_HUMAN)

Names and origin

Protein names

Recommended name:
    Probable ribosome biogenesis protein RLP24
Alternative name(s):
    Ribosomal protein L24-like

Gene names

Name:	C15orf15
Synonyms:	RPL24L
ORF Names:	My024

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	163 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles By similarity.
Subunit structure	Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24 By similarity.
Subcellular location	Nucleus › nucleolus.
Sequence similarities	Belongs to the ribosomal protein L24e family.

Ontologies

Keywords
Biological process	Ribosome biogenesis
Cellular component	Nucleus
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 163	163	Probable ribosome biogenesis protein RLP24
Experimental info
	Sequence conflict	29	1	F → I in AAH08499. Ref.6
	Sequence conflict	30	1	R → G in AAH14576. Ref.6
	Sequence conflict	45	1	N → D in AAH28672. Ref.6
	Sequence conflict	86	1	W → R in AAH16312. Ref.6
	Sequence conflict	146	1	E → G in AAH28672. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Q9UHA3-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 1E5D9ECFFCF678D1	FASTA	163	19,621
	10 20 30 40 50 60 MRIEKCYFCS GPIYPGHGMM FVRNDCKVFR FCKSKCHKNF KKKRNPRKVR WTKAFRKAAG 70 80 90 100 110 120 KELTVDNSFE FEKRRNEPIK YQRELWNKTI DAMKRVEEIK QKRQAKFIMN RLKKNKELQK 130 140 150 160 VQDIKEVKQN IHLIRAPLAG KGKQLEEKMV QQLQEDVDME DAP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel genes expressed in human dendritic cells." Li Y., Peng Y., Li N., Gu W., Han Z., Fu G., Chen Z. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Dendritic cell.
[2]	Mao Y.M., Xie Y., Lin Q., Mu Z.M., Yuan Y.Z. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fetal brain.
[3]	"Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients." Gu J., Huang Q., Yu Y., Xu S., Wang Y., Han Z., Chen Z., Zhou J., Tu Y., Gu W., Fu G., Huang C. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hematopoietic stem cell.
[4]	"A novel gene expressed in human liver." Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[5]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood, Bone marrow, Brain, Lung and Urinary bladder.
[7]	"Functional proteomic analysis of human nucleolus." Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. Mol. Biol. Cell 13:4100-4109(2002) [PubMed: 12429849] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF201949 mRNA. Translation: AAF17241.1. AF060926 mRNA. Translation: AAG43138.1. AF165521 mRNA. Translation: AAF86651.1. AF212226 mRNA. Translation: AAK26249.1. CR457179 mRNA. Translation: CAG33460.1. BC008409 mRNA. Translation: AAH08409.1. BC008422 mRNA. Translation: AAH08422.1. BC008449 mRNA. Translation: AAH08449.1. BC008499 mRNA. Translation: AAH08499.1. BC009593 mRNA. Translation: AAH09593.1. BC009604 mRNA. Translation: AAH09604.1. BC012913 mRNA. Translation: AAH12913.1. BC014576 mRNA. Translation: AAH14576.1. BC016312 mRNA. Translation: AAH16312.1. BC016331 mRNA. Translation: AAH16331.1. BC016725 mRNA. Translation: AAH16725.1. BC016777 mRNA. Translation: AAH16777.1. BC026266 mRNA. Translation: AAH26266.1. BC026267 mRNA. Translation: AAH26267.1. BC028672 mRNA. Translation: AAH28672.1. BC035995 mRNA. Translation: AAH35995.1. BC093067 mRNA. Translation: AAH93067.1.
RefSeq	NP_057388.1.
UniGene	Hs.274772 Hs.593056
3D structure databases
ModBase	Search...
2-D gel databases
SWISS-2DPAGE	Q9UHA3.
Genome annotation databases
Ensembl	ENSG00000137876. Homo sapiens. [Contig view]
GeneID	51187.
KEGG	hsa:51187.
Organism-specific databases
HGNC	HGNC:18479. C15orf15.
PharmGKB	PA38548.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	Q9UHA3.
HOVERGEN	Q9UHA3.
Gene expression databases
ArrayExpress	Q9UHA3.
CleanEx	HS_C15orf15.
GermOnline	ENSG00000137876. Homo sapiens.
Family and domain databases
InterPro	IPR000988. Ribosomal_L24e. IPR011017. TRASH. [Graphical view]
Gene3D	G3DSA:2.30.170.20. Ribosomal_L24E. 1 hit.
PANTHER	PTHR10792. Ribosomal_L24E. 1 hit.
Pfam	PF01246. Ribosomal_L24e. 1 hit. [Graphical view]
SMART	SM00746. TRASH. 1 hit. [Graphical view]
PROSITE	PS01073. RIBOSOMAL_L24E. 1 hit. [Graphical view]
ProDom	Q9UHA3. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	Q9UHA3.
ProtoNet	Search...

Entry information

Entry name

RLP24_HUMAN

Accession

Primary (citable) accession number: Q9UHA3
Secondary accession number(s): Q561V8 , Q8N6S8, Q96B04, Q96C76, Q96HJ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	May 1, 2000
Last modified:	July 22, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)