Reviewed, UniProtKB/Swiss-Prot Q9UJX3 (APC7_HUMAN)

Names and origin

Protein names

Recommended name:
    Anaphase-promoting complex subunit 7
      Short name(s)=APC7
Alternative name(s):
    Cyclosome subunit 7

Gene names

Name:	ANAPC7
Synonyms:	APC7

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	565 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.
Pathway	Protein modification; protein ubiquitination.
Subunit structure	The APC/C is composed of at least 11 subunits.
Sequence similarities	Belongs to the APC7 family. Contains 7 TPR repeats.
Sequence caution	AAH17316.2 sequence differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis Ubl conjugation pathway
Domain	Repeat TPR repeat
Gene Ontology (GO)
Biological process	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Inferred from Experiment. Source: Reactome negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle Inferred from Experiment. Source: Reactome positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle Inferred from Experiment. Source: Reactome
Cellular component	cytosol Inferred from Experiment. Source: Reactome nucleoplasm Inferred from Experiment. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 565	565	Anaphase-promoting complex subunit 7
Regions
	Repeat	43 – 76	34	TPR 1
	Repeat	135 – 168	34	TPR 2
	Repeat	237 – 270	34	TPR 3
	Repeat	339 – 372	34	TPR 4
	Repeat	407 – 441	35	TPR 5
	Repeat	442 – 474	33	TPR 6
	Repeat	475 – 508	34	TPR 7
Experimental info
	Sequence conflict	150	1	Q → R in AAF05754. Ref.1
	Sequence conflict	268	1	P → L in AAF05754. Ref.1
	Sequence conflict	503	1	S → R in CAB70828. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9UJX3-1 [UniParc]. Last modified October 17, 2006. Version 3. Checksum: B86B7145E9E03EC3	FASTA	565	63,133
	10 20 30 40 50 60 MNVIDHVRDM AAAGLHSNVR LLSSLLLTMS NNNPELFSPP QKYQLLVYHA DSLFHDKEYR 70 80 90 100 110 120 NAVSKYTMAL QQKKALSKTS KVRPSTGNSA STPQSQCLPS EIEVKYKMAE CYTMLKQDKD 130 140 150 160 170 180 AIAILDGIPS RQRTPKINMM LANLYKKAGQ ERPSVTSYKE VLRQCPLALD AILGLLSLSV 190 200 210 220 230 240 KGAEVASMTM NVIQTVPNLD WLSVWIKAYA FVHTGDNSRA ISTICSLEKK SLLRDNVDLL 250 260 270 280 290 300 GSLADLYFRA GDNKNSVLKF EQAQMLDPYL IKGMDVYGYL LAREGRLEDV ENLGCRLFNI 310 320 330 340 350 360 SDQHAEPWVV SGCHSFYSKR YSRALYLGAK AIQLNSNSVQ ALLLKGAALR NMGRVQEAII 370 380 390 400 410 420 HFREAIRLAP CRLDCYEGLI ECYLASNSIR EAMVMANNVY KTLGANAQTL TLLATVCLED 430 440 450 460 470 480 PVTQEKAKTL LDKALTQRPD YIKAVVKKAE LLSREQKYED GIALLRNALA NQSDCVLHRI 490 500 510 520 530 540 LGDFLVAVNE YQEAMDQYSI ALSLDPNDQK SLEGMQKMEK EESPTDATQE EDVDDMEGSG 550 560 EEGDLEGSDS EAAQWADQEQ WFGMQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a cullin homology region in a subunit of the anaphase-promoting complex." Yu H., Peters J.-M., King R.W., Page A.M., Hieter P., Kirschner M.W. Science 279:1219-1222(1998) [PubMed: 9469815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 110-565. Tissue: Ovary and Skin.
[3]	The German cDNA consortium Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 282-503. Tissue: Testis.
[4]	"Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C." Dube P., Herzog F., Gieffers C., Sander B., Riedel D., Mueller S.A., Engel A., Peters J.-M., Stark H. Mol. Cell 20:867-879(2005) [PubMed: 16364912] [Abstract] Cited for: ELECTRON MICROSCOPY OF THE APC/C.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF191340 mRNA. Translation: AAF05754.1. BC002941 mRNA. Translation: AAH02941.2. BC009498 mRNA. Translation: AAH09498.2. BC017316 mRNA. Translation: AAH17316.2. Sequence problems. AL137586 mRNA. Translation: CAB70828.1.
PIR	T46297.
RefSeq	NP_057322.1.
UniGene	Hs.529280
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9UJX3.
PTM databases
PhosphoSite	Q9UJX3.
Proteomic databases
PeptideAtlas	Q9UJX3.
Genome annotation databases
Ensembl	ENSG00000196510. Homo sapiens. [Contig view]
GeneID	51434.
KEGG	hsa:51434.
NMPDR	fig|9606.3.peg.8242.
Organism-specific databases
HGNC	HGNC:17380. ANAPC7.
HPA	CAB009567.
MIM	606949. gene.
PharmGKB	PA134901290.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	Q9UJX3.
HOVERGEN	Q9UJX3.
Enzyme and pathway databases
Reactome	REACT_152. Cell Cycle, Mitotic. REACT_1538. Cell Cycle Checkpoints. REACT_6850. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. REACT_8017. APC-Cdc20 mediated degradation of Nek2A. REACT_9035. APC/C:Cdh1-mediated degradation of Skp2.
Gene expression databases
ArrayExpress	Q9UJX3.
CleanEx	HS_ANAPC7.
GermOnline	ENSG00000196510. Homo sapiens.
Family and domain databases
InterPro	IPR001440. TPR-1. IPR011990. TPR-like_helical. IPR013105. TPR_2. IPR013026. TPR_region. [Graphical view]
Gene3D	G3DSA:1.25.40.10. TPR-like_helical. 2 hits.
Pfam	PF00515. TPR_1. 2 hits. PF07719. TPR_2. 1 hit. [Graphical view]
SMART	SM00028. TPR. 4 hits. [Graphical view]
PROSITE	PS50005. TPR. 5 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProDom	Q9UJX3. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

APC7_HUMAN

Accession

Primary (citable) accession number: Q9UJX3
Secondary accession number(s): Q96AC4 , Q96GF4, Q9BU24, Q9NT16

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	October 17, 2006
Last modified:	July 22, 2008
This is version 67 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)