Reviewed,
UniProtKB/Swiss-Prot Q9UJX5 (APC4_HUMAN)
Last modified
July 22, 2008.
Version 53.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Anaphase-promoting complex subunit 4 Short name(s)=APC4 Alternative name(s): Cyclosome subunit 4 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 808 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. |
| Pathway | |
| Subunit structure | The APC/C is composed of at least 11 subunits. |
| Sequence similarities | Belongs to the APC4 family. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | |||||
| Isoform 1 (identifier: Q9UJX5-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | |||||
| Isoform 2 (identifier: Q9UJX5-2) The sequence of this isoform differs from the canonical sequence as follows: 542-551: DVIGKSMNQA → VSLKEMHVFV 552-808: Missing. | |||||
| Notes: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 808 | 808 | Anaphase-promoting complex subunit 4 | |||||
Amino acid modifications | ||||||||
| Modified residue | 469 | 1 | Phosphotyrosine | |||||
| Modified residue | 779 | 1 | Phosphoserine | |||||
Natural variations | ||||||||
| Alternative sequence | 542 – 551 | 10 | DVIGKSMNQA → VSLKEMHVFV in isoform 2. | |||||
| Alternative sequence | 552 – 808 | 257 | Missing in isoform 2. | |||||
| Natural variant | 155 | 1 | I → V in a colorectal cancer sample; somatic mutation. | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Identification of a cullin homology region in a subunit of the anaphase-promoting complex." Yu H., Peters J.-M., King R.W., Page A.M., Hieter P., Kirschner M.W. Science 279:1219-1222(1998) [PubMed: 9469815] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBUNIT. |
| [2] | The German cDNA consortium Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 434-808 (ISOFORM 2). Tissue: Amygdala. |
| [3] | "Mitotic regulation of the human anaphase-promoting complex by phosphorylation." Kraft C., Herzog F., Gieffers C., Mechtler K., Hagting A., Pines J., Peters J.-M. EMBO J. 22:6598-6609(2003) [PubMed: 14657031] [Abstract] Cited for: PHOSPHORYLATION AT TYR-469 AND SER-779. |
| [4] | "Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C." Dube P., Herzog F., Gieffers C., Sander B., Riedel D., Mueller S.A., Engel A., Peters J.-M., Stark H. Mol. Cell 20:867-879(2005) [PubMed: 16364912] [Abstract] Cited for: ELECTRON MICROSCOPY OF THE APC/C. |
| [5] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.  Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-155. |
Cross-references
Sequence databases | |
|---|---|
| AF191338 mRNA. Translation: AAF05752.1. AL353932 mRNA. Translation: CAB89245.1. | |
| PIR | T48682. |
| UniGene | Hs.152173 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q9UJX5. |
Genome annotation databases | |
| Ensembl | ENSG00000053900. Homo sapiens. [Contig view] |
Organism-specific databases | |
| H-InvDB | HIX0020484. |
| HGNC | HGNC:19990. ANAPC4. |
| MIM | 606947. gene. |
| PharmGKB | PA134894250. |
| GenAtlas | Search... |
| GeneCards | Search... |
| GeneLynx | Search... |
Phylogenomic databases | |
| HOGENOM | Q9UJX5. |
| HOVERGEN | Q9UJX5. |
Enzyme and pathway databases | |
| Reactome | REACT_152. Cell Cycle, Mitotic. REACT_1538. Cell Cycle Checkpoints. REACT_6850. Cdc20:Phospho-APC/C mediated degradation of Cyclin A. REACT_8017. APC-Cdc20 mediated degradation of Nek2A. REACT_9035. APC/C:Cdh1-mediated degradation of Skp2. |
Gene expression databases | |
| ArrayExpress | Q9UJX5. |
| CleanEx | HS_ANAPC4. |
| GermOnline | ENSG00000053900. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR017169. Anaphase-prom_comp_su4. IPR015943. WD40/YVTN_repeat-like. [Graphical view] |
| Gene3D | G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit. |
| PIRSF | PIRSF037303. APC4. 1 hit. |
| ProDom | Q9UJX5. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| SOURCE | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | APC4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9UJX5 Secondary accession number(s): Q9NSH6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |
