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Reviewed, UniProtKB/Swiss-Prot Q9UKF5 (ADA29_HUMAN)

Last modified July 22, 2008. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    ADAM 29
Alternative name(s):
    A disintegrin and metalloproteinase domain 29
    Cancer/testis antigen 73
      Short name(s)=CT73
Gene names
Name: ADAM29
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length820 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed specifically in testes.

Sequence similarities

Contains 1 disintegrin domain.

Contains 1 EGF-like domain.

Contains 1 peptidase M12B domain.

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Ontologies

Keywords

   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainEGF-like domain
Repeat
Signal
Transmembrane
   PTMGlycoprotein

Gene Ontology (GO)

   Biological processspermatogenesis Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentintegral to plasma membrane Ref.1

Traceable author statement. Source: ProtInc

   Molecular functionmetallopeptidase activity Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform Alpha (identifier: Q9UKF5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Beta (identifier: Q9UKF5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     750-803: Missing.
Isoform Gamma (identifier: Q9UKF5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     763-787: VTPSQSQPRVMPSQSQPPVMPSQSH → QNLFLFSFSISDCVLNFRLLYLQAT
     788-820: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 193175 By similarity
Chain194 – 820627ADAM 29

Regions

Topological domain194 – 674481Extracellular Potential
Transmembrane675 – 69521 Potential
Topological domain696 – 820125Cytoplasmic Potential
Domain198 – 390193Peptidase M12B
Domain397 – 48387Disintegrin
Domain625 – 65430EGF-like
Repeat739 – 74791
Repeat748 – 75692
Repeat757 – 76593
Repeat766 – 77494
Repeat775 – 78395
Repeat784 – 79296
Repeat793 – 80197
Repeat802 – 81098
Repeat811 – 81999
Region739 – 819819 X 9 AA approximate repeats
Compositional bias484 – 624141Cys-rich
Compositional bias669 – 6757Poly-Lys

Amino acid modifications

Glycosylation2171N-linked (GlcNAc...) Potential
Glycosylation3201N-linked (GlcNAc...) Potential
Glycosylation3681N-linked (GlcNAc...) Potential
Glycosylation4281N-linked (GlcNAc...) Potential
Glycosylation4691N-linked (GlcNAc...) Potential
Glycosylation5381N-linked (GlcNAc...) Potential
Glycosylation5451N-linked (GlcNAc...) Potential
Glycosylation5581N-linked (GlcNAc...) Potential
Glycosylation5641N-linked (GlcNAc...) Potential
Disulfide bond307 ↔ 384 By similarity
Disulfide bond347 ↔ 369 By similarity
Disulfide bond349 ↔ 354 By similarity
Disulfide bond455 ↔ 475 By similarity
Disulfide bond625 ↔ 636 By similarity
Disulfide bond630 ↔ 642 By similarity
Disulfide bond644 ↔ 653 By similarity

Natural variations

Alternative sequence750 – 80354Missing in isoform Beta.
Alternative sequence763 – 78725VTPSQ…PSQSH → QNLFLFSFSISDCVLNFRLL YLQAT in isoform Gamma.
Alternative sequence788 – 82033Missing in isoform Gamma.
Natural variant311P → L in a colorectal cancer sample; somatic mutation.
Natural variant2051V → I in a colorectal cancer sample; somatic mutation.

Experimental info

Sequence conflict1961H → Y in AAF22163. Ref.2
Sequence conflict7441P → H in AAF22163. Ref.2
Sequence conflict7481S → Y in AAF22163. Ref.2
Sequence conflict7531Q → R in AAF03777. Ref.1
Sequence conflict7641T → M in AAF03777. Ref.1
Sequence conflict769 – 7735QPRVM → HPQLT in AAF03777. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Isoform Alpha [UniParc].

Last modified April 17, 2007. Version 3.
Checksum: AA2FB11342A884C9

FASTA82092,759
        10         20         30         40         50         60 
MKMLLLLHCL GVFLSCSGHI QDEHPQYHSP PDVVIPVRIT GTTRGMTPPG WLSYILPFGG 

        70         80         90        100        110        120 
QKHIIHIKVK KLLFSKHLPV FTYTDQGAIL EDQPFVQNNC YYHGYVEGDP ESLVSLSTCF 

       130        140        150        160        170        180 
GGFQGILQIN DFAYEIKPLA FSTTFEHLVY KMDSEEKQFS TMRSGFMQNE ITCRMEFEEI 

       190        200        210        220        230        240 
DNSTQKQSSY VGWWIHFRIV EIVVVIDNYL YIRYERNDSK LLEDLYVIVN IVDSILDVIG 

       250        260        270        280        290        300 
VKVLLFGLEI WTNKNLIVVD DVRKSVHLYC KWKSENITPR MQHDTSHLFT TLGLRGLSGI 

       310        320        330        340        350        360 
GAFRGMCTPH RSCAIVTFMN KTLGTFSIAV AHHLGHNLGM NHDEDTCRCS QPRCIMHEGN 

       370        380        390        400        410        420 
PPITKFSNCS YGDFWEYTVE RTKCLLETVH TKDIFNVKRC GNGVVEEGEE CDCGPLKHCA 

       430        440        450        460        470        480 
KDPCCLSNCT LTDGSTCAFG LCCKDCKFLP SGKVCRKEVN ECDLPEWCNG TSHKCPDDFY 

       490        500        510        520        530        540 
VEDGIPCKER GYCYEKSCHD RNEQCRRIFG AGANTASETC YKELNTLGDR VGHCGIKNAT 

       550        560        570        580        590        600 
YIKCNISDVQ CGRIQCENVT EIPNMSDHTT VHWARFNDIM CWSTDYHLGM KGPDIGEVKD 

       610        620        630        640        650        660 
GTECGIDHIC IHRHCVHITI LNSNCSPAFC NKRGICNNKH HCHCNYLWDP PNCLIKGYGG 

       670        680        690        700        710        720 
SVDSGPPPKR KKKKKFCYLC ILLLIVLFIL LCCLYRLCKK SKPIKKQQDV QTPSAKEEEK 

       730        740        750        760        770        780 
IQRRPHELPP QSQPWVMPSQ SQPPVTPSQS HPQVMPSQSQ PPVTPSQSQP RVMPSQSQPP 

       790        800        810        820 
VMPSQSHPQL TPSQSQPPVT PSQRQPQLMP SQSQPPVTPS

« Hide

Isoform Beta [UniParc].

Checksum: ACA4BEDFA700ABA5
Show »

76686,983
Isoform Gamma [UniParc].

Checksum: 2B0E5E7C496B8C9D
Show »

78789,460

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References

« Hide 'large scale' references
[1]"Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expression."
Cerretti D.P., DuBose R.F., Black R.A., Nelson N.
Biochem. Biophys. Res. Commun. 263:810-815(1999) [PubMed: 10512762] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; BETA AND GAMMA).
Tissue: Testis.
[2]"Molecular cloning and mapping of a novel ADAM gene (ADAM29) to human chromosome 4."
Xu R., Cai J., Xu T., Zhou W., Ying B., Deng K., Zhao S., Li C.
Genomics 62:537-539(1999) [PubMed: 10644455] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
Tissue: Testis.
[3]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed: 16959974] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-31 AND ILE-205.

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Cross-references

Sequence databases

AF171929 mRNA. Translation: AAF03777.1.
AF171930 mRNA. Translation: AAF03778.1.
AF171931 mRNA. Translation: AAF03779.1.
AF134708 mRNA. Translation: AAF22163.1.
RefSeqNP_055084.3.
UniGeneHs.126838

3D structure databases

HSSPHSSP built from PDB template 1FVL based on UniProtKB P18619.
ModBaseSearch...

Protein family/group databases

MEROPSM12.981.

Genome annotation databases

EnsemblENSG00000168594. Homo sapiens. [Contig view]
GeneID11086.
KEGGhsa:11086.

Organism-specific databases

HGNCHGNC:207. ADAM29.
HPAHPA014159.
MIM604778. gene.
PharmGKBPA24524.
GenAtlasSearch...
GeneCardsSearch...
GeneLynxSearch...

Phylogenomic databases

HOGENOMQ9UKF5.
HOVERGENQ9UKF5.

Gene expression databases

ArrayExpressQ9UKF5.
CleanExHS_ADAM29.
GermOnlineENSG00000168594. Homo sapiens.

Family and domain databases

InterProIPR006586. ADAM_cysteine.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR000742. EGF_3.
IPR013032. EGF_like_reg_CS.
IPR006025. Pept_M_Zn_BS.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
Gene3DG3DSA:4.10.70.10. Blood-coag_inhib_Disintegrin. 1 hit.
PfamPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSPR00289. DISINTEGRIN.
ProDomPD000664. Disintegrin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
[Graphical view]
PROSITEPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. False negative.
PS01186. EGF_2. False negative.
PS50026. EGF_3. False negative.
PS00142. ZINC_PROTEASE. False negative.
[Graphical view]
BLOCKSSearch...

Other Resources

LinkHubQ9UKF5.
SOURCESearch...
ProtoNetSearch...

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Entry information

Entry nameADA29_HUMAN
AccessionPrimary (citable) accession number: Q9UKF5
Secondary accession number(s): Q9UHP1, Q9UKF3, Q9UKF4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: April 17, 2007
Last modified: July 22, 2008
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Peptidase families

Classification of peptidase families and list of entries

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents