Reviewed, UniProtKB/Swiss-Prot Q9UKP5 (ATS6_HUMAN)

Names and origin

Protein names

Recommended name:
    A disintegrin and metalloproteinase with thrombospondin motifs 6
      Short name=ADAMTS-6
      Short name=ADAM-TS 6
      Short name=ADAM-TS6
    EC=3.4.24.-

Gene names

Name:

ADAMTS6

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	860 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Cofactor	Binds 1 zinc ion per subunit By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrixBy similarity.
Tissue specificity	Expressed at low levels in placenta and barely detectable in a number of other tissues.
Domain	The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
Post-translational modification	The precursor is cleaved by a furin endopeptidase By similarity.
Sequence similarities	Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. Contains 2 TSP type-1 domains.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Repeat Signal
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
PTM	Cleavage on pair of basic residues Glycoprotein Zymogen
Gene Ontology (GO)
Molecular function	metallopeptidase activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Propeptide	22 – 244	223	By similarity		PRO_0000029174
	Chain	245 – 860	616	A disintegrin and metalloproteinase with thrombospondin motifs 6		PRO_0000029175
Regions
	Domain	250 – 452	203	Peptidase M12B
	Domain	453 – 509	57	Disintegrin
	Domain	510 – 565	56	TSP type-1 1
	Domain	796 – 852	57	TSP type-1 2
	Region	669 – 795	127	Spacer
	Compositional bias	68 – 71	4	Poly-Arg
	Compositional bias	567 – 668	102	Cys-rich
	Compositional bias	662 – 665	4	Poly-Gly
Sites
	Active site	404	1	By similarity
	Metal binding	403	1	Zinc; catalytic By similarity
	Metal binding	407	1	Zinc; catalytic By similarity
	Metal binding	413	1	Zinc; catalytic By similarity
Amino acid modifications
	Glycosylation	99	1	N-linked (GlcNAc...) Potential
	Glycosylation	172	1	N-linked (GlcNAc...) Potential
	Glycosylation	222	1	N-linked (GlcNAc...) Potential
	Glycosylation	234	1	N-linked (GlcNAc...) Potential
	Glycosylation	676	1	N-linked (GlcNAc...) Potential
	Glycosylation	843	1	N-linked (GlcNAc...) Potential
	Disulfide bond	522 ↔ 559		By similarity
	Disulfide bond	526 ↔ 564		By similarity
	Disulfide bond	537 ↔ 549		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9UKP5-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: E57213015DECB2C5	FASTA	860	97,100
	10 20 30 40 50 60 MEILWKTLTW ILSLIMASSE FHSDHRLSYS SQEEFLTYLE HYQLTIPIRV DQNGAFLSFT 70 80 90 100 110 120 VKNDKHSRRR RSMDPIDPQQ AVSKLFFKLS AYGKHFHLNL TLNTDFVSKH FTVEYWGKDG 130 140 150 160 170 180 PQWKHDFLDN CHYTGYLQDQ RSTTKVALSN CVGLHGVIAT EDEEYFIEPL KNTTEDSKHF 190 200 210 220 230 240 SYENGHPHVI YKKSALQQRH LYDHSHCGVS DFTRSGKPWW LNDTSTVSYS LPINNTHIHH 250 260 270 280 290 300 RQKRSVSIER FVETLVVADK MMVGYHGRKD IEHYILSVMN IVAKLYRDSS LGNVVNIIVA 310 320 330 340 350 360 RLIVLTEDQP NLEINHHADK SLDSFCKWQK SILSHQSDGN TIPENGIAHH DNAVLITRYD 370 380 390 400 410 420 ICTYKNKPCG TLGLASVAGM CEPERSCSIN EDIGLGSAFT IAHEIVHNFG MNHDGIGNSC 430 440 450 460 470 480 GRKVMKQQNY GSSHYCEYQS FFLVCLQSRX HHQLFREVCR ELWCLSKSNR CVTNSIPAAE 490 500 510 520 530 540 GTLCQTGNIE KGWCYQGDCV PFGTWPQSID GGWGPWSLWG ECSRTCGGGV SSSLRHCDSP 550 560 570 580 590 600 APSGGGKYCL GERKRYRSCN TDPCPLGSRD FREKQCADFD NMPFRGKYYN WKPYTGGGVK 610 620 630 640 650 660 PCALNCLAEG YNFYTERAPA VIDGTQCNAD SLDICINGEC KHVGCDNILG SDAREDRCRV 670 680 690 700 710 720 CGGGGSTCDA IEGFFNDSLP RGGYMEVVQI PRGSVHIEVR EVAMSKNYIA LKSEGDDYYI 730 740 750 760 770 780 NGAWTIDWPR KFDVAGTAFH YKRPTDEPES LEALGPTSEN LIVMVLLQEQ NLGIRYKFNV 790 800 810 820 830 840 PITRTGSGDN EVGFTWNHQP WSECSATCAG GKMPTRQPTQ RARWRTKHIL SYALCLLKKL 850 860 IGNISCRFAS SCNLAKETLL

References

[1]	"ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases." Hurskainen T.L., Hirohata S., Seldin M.F., Apte S.S. J. Biol. Chem. 274:25555-25563(1999) [PubMed: 10464288] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF140674 mRNA. Translation: AAD56357.1.
UniGene	Hs.482291
3D structure databases
HSSP	HSSP built from PDB template 1LSL based on UniProtKB P07996.
ModBase	Search...
Protein family/group databases
MEROPS	M12.230.
Genome annotation databases
Ensembl	ENSG00000049192. Homo sapiens. [Contig view]
Organism-specific databases
H-InvDB	HIX0024828.
HGNC	HGNC:222. ADAMTS6.
MIM	605008. gene.
PharmGKB	PA24550.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q9UKP5.
Gene expression databases
ArrayExpress	Q9UKP5.
CleanEx	HS_ADAMTS6.
GermOnline	ENSG00000049192. Homo sapiens.
Family and domain databases
InterPro	IPR010294. ADAM_spacer1. IPR001762. Blood-coag_inhib_Disintegrin. IPR006025. Pept_M_Zn_BS. IPR001590. Peptidase_M12B. IPR013273. Peptidase_M12B_ADAM-TS. IPR002870. Peptidase_M12B_N. IPR000884. TSP1. IPR008085. TSP_1. [Graphical view]
Pfam	PF05986. ADAM_spacer1. 1 hit. PF01562. Pep_M12B_propep. 1 hit. PF01421. Reprolysin. 1 hit. PF00090. TSP_1. 1 hit. [Graphical view]
PRINTS	PR01857. ADAMTSFAMILY. PR01705. TSP1REPEAT.
SMART	SM00209. TSP1. 1 hit. [Graphical view]
PROSITE	PS50215. ADAM_MEPRO. 1 hit. PS00427. DISINTEGRIN_1. False negative. PS50214. DISINTEGRIN_2. False negative. PS50092. TSP1. 1 hit. PS00142. ZINC_PROTEASE. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

ATS6_HUMAN

Accession

Primary (citable) accession number: Q9UKP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	September 2, 2008
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)