Reviewed, UniProtKB/Swiss-Prot Q9UL15 (BAG5_HUMAN)

Names and origin

Protein names

Recommended name:
    BAG family molecular chaperone regulator 5
      Short name=BAG-5
Alternative name(s):
    Bcl-2-associated athanogene 5

Gene names

Name:	BAG5
Synonyms:	KIAA0873

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 By similarity.
Subunit structure	Binds to the ATPase domain of HSP70/HSC chaperones. Binds PARK2 By similarity.
Sequence similarities	Contains 4 BAG domains.

Ontologies

Keywords
Domain	Repeat
Molecular function	Chaperone
Technical term	3D-structure
Gene Ontology (GO)
Biological process	protein folding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 447	447	BAG family molecular chaperone regulator 5
Regions
	Domain	9 – 86	78	BAG 1
	Domain	182 – 260	79	BAG 2
	Domain	275 – 350	76	BAG 3
	Domain	365 – 442	78	BAG 4
Experimental info
	Sequence conflict	157	1	C → W in AAH50551. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9UL15-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 0D3F7EA6B612C1F5	FASTA	447	51,200
	10 20 30 40 50 60 MDMGNQHPSI SRLQEIQKEV KSVEQQVIGF SGLSDDKNYK KLERILTKQL FEIDSVDTEG 70 80 90 100 110 120 KGDIQQARKR AAQETERLLK ELEQNANHPH RIEIQNIFEE AQSLVREKIV PFYNGGNCVT 130 140 150 160 170 180 DEFEEGIQDI ILRLTHVKTG GKISLRKARY HTLTKICAVQ EIIEDCMKKQ PSLPLSEDAH 190 200 210 220 230 240 PSVAKINFVM CEVNKARGVL IALLMGVNNN ETCRHLSCVL SGLIADLDAL DVCGRTEIRN 250 260 270 280 290 300 YRREVVEDIN KLLKYLDLEE EADTTKAFDL RQNHSILKIE KVLKRMREIK NELLQAQNPS 310 320 330 340 350 360 ELYLSSKTEL QGLIGQLDEV SLEKNPCIRE ARRRAVIEVQ TLITYIDLKE ALEKRKLFAC 370 380 390 400 410 420 EEHPSHKAVW NVLGNLSEIQ GEVLSFDGNR TDKNYIRLEE LLTKQLLALD AVDPQGEEKC 430 440 KAARKQAVRL AQNILSYLDL KSDEWEY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators." Takayama S., Xie Z., Reed J.C. J. Biol. Chem. 274:781-786(1999) [PubMed: 9873016] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed: 10048485] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Solution structure of the BAG domain (275-350) of BAG-family molecular chaperone regulator-5." RIKEN structural genomics initiative (RSGI) Submitted (DEC-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 275-351.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AF095195 mRNA. Translation: AAD16124.2.
AB020680 mRNA. Translation: BAA74896.1. Different initiation.
BC044216 mRNA. Translation: AAH44216.2. Different initiation.
BC050551 mRNA. Translation: AAH50551.1.

RefSeq

NP_001015048.1.
NP_001015049.1.
NP_004864.1.

UniGene

Hs.5443

3D structure databases

PDBMSD

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2D9D	NMR	-	A	275-351	[»]

SMR

Q9UL15. Positions 1-89.

ModBase

Search...

Genome annotation databases

Ensembl

ENSG00000166170. Homo sapiens. [Contig view]

GeneID

9529.

KEGG

hsa:9529.

Organism-specific databases

H-InvDB

HIX0012003.

HGNC

HGNC:941. BAG5.

HPA

HPA016429.

MIM

603885. gene.

PharmGKB

PA25241.

HUGE

Search...

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

Q9UL15.

HOVERGEN

Q9UL15.

Gene expression databases

ArrayExpress

Q9UL15.

CleanEx

HS_BAG5.

GermOnline

ENSG00000166170. Homo sapiens.

Family and domain databases

InterPro

IPR003103. BAG.
[Graphical view]

Pfam

PF02179. BAG. 4 hits.
[Graphical view]

SMART

SM00264. BAG. 4 hits.
[Graphical view]

PROSITE

PS51035. BAG. 4 hits.
[Graphical view]

ProDom

Q9UL15.
[Graphical view] [Entries sharing at least one domain]

BLOCKS

Search...

Other Resources

SOURCE

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ProtoNet

Search...

Entry information

Entry name

BAG5_HUMAN

Accession

Primary (citable) accession number: Q9UL15
Secondary accession number(s): O94950, Q86W59

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 2000
Last modified:	July 22, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)