Reviewed, UniProtKB/Swiss-Prot Q9ULJ7 (ANR50_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 50

Gene names

Name:	ANKRD50
Synonyms:	KIAA1223

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1375 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 19 ANK repeats.

Ontologies

Keywords
Domain	ANK repeat Repeat
PTM	Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 1375	1375	Ankyrin repeat domain-containing protein 50
Regions
	Repeat	423 – 455	33	ANK 1
	Repeat	457 – 486	30	ANK 2
	Repeat	490 – 519	30	ANK 3
	Repeat	523 – 552	30	ANK 4
	Repeat	556 – 585	30	ANK 5
	Repeat	589 – 618	30	ANK 6
	Repeat	622 – 651	30	ANK 7
	Repeat	655 – 689	35	ANK 8
	Repeat	693 – 722	30	ANK 9
	Repeat	726 – 755	30	ANK 10
	Repeat	759 – 788	30	ANK 11
	Repeat	792 – 821	30	ANK 12
	Repeat	825 – 854	30	ANK 13
	Repeat	858 – 887	30	ANK 14
	Repeat	891 – 920	30	ANK 15
	Repeat	924 – 953	30	ANK 16
	Repeat	957 – 986	30	ANK 17
	Repeat	990 – 1019	30	ANK 18
	Repeat	1023 – 1053	31	ANK 19
	Compositional bias	1069 – 1238	170	Ser-rich
Amino acid modifications
	Modified residue	1168	1	Phosphoserine
Experimental info
	Sequence conflict	227	1	R → Q in CAE45806. Ref.2
	Sequence conflict	593	1	A → V in BAA86537. Ref.3
	Sequence conflict	602	1	H → R in BAC87007. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9ULJ7-1 [UniParc]. Last modified March 7, 2006. Version 3. Checksum: A8C545F530068F00	FASTA	1,375	149,589
	10 20 30 40 50 60 MNSGNNASGV SGKGAAWGVL LVGGPGSGKT ALCTELLWPS SPASLQRGLH RQALAFHFCK 70 80 90 100 110 120 AQDSDTLCVG GFIRGLVAQI CRSGLLQGYE DKLRDPAVQS LLQPGECERN PAEAFKRCVL 130 140 150 160 170 180 LPLLGMKPPQ QSLYLLVDSV DEGCNITEGE QTSTSLSGTV AALLAGHHEF FPPWLLLLCS 190 200 210 220 230 240 ARKQSKAVTK MFTGFRKISL DDLRKAYIVK DVQQYILHRL DQEEALRQHL TKETAEMLNQ 250 260 270 280 290 300 LHIKSSGCFL YLERVLDGVV ENFIMLREIR DIPGTLNGLY LWLCQRLFVR KQFAKVQPIL 310 320 330 340 350 360 NVILAACRPL TITELYHAVW TKNMSLTLED FQRKLDILSK LLVDGLGNTK ILFHYSFAEW 370 380 390 400 410 420 LLDVKHCTQK YLCNAAEGHR MLAMSYTCQA KNLTPLEAQE FALHLINSNL QLETAELALW 430 440 450 460 470 480 MIWNGTPVRD SLSTLIPKEQ EVLQLLVKAG AHVNSEDDRT SCIVRQALER EDSIRTLLDN 490 500 510 520 530 540 GASVNQCDSN GRTLLANAAY SGSLDVVNLL VSRGADLEIE DAHGHTPLTL AARQGHTKVV 550 560 570 580 590 600 NCLIGCGANI NHTDQDGWTA LRSAAWGGHT EVVSALLYAG VKVDCADADS RTALRAAAWG 610 620 630 640 650 660 GHEDIVLNLL QHGAEVNKAD NEGRTALIAA AYMGHREIVE HLLDHGAEVN HEDVDGRTAL 670 680 690 700 710 720 SVAALCVPAS KGHASVVSLL IDRGAEVDHC DKDGMTPLLV AAYEGHVDVV DLLLEGGADV 730 740 750 760 770 780 DHTDNNGRTP LLAAASMGHA SVVNTLLFWG AAVDSIDSEG RTVLSIASAQ GNVEVVRTLL 790 800 810 820 830 840 DRGLDENHRD DAGWTPLHMA AFEGHRLICE ALIEQGARTN EIDNDGRIPF ILASQEGHYD 850 860 870 880 890 900 CVQILLENKS NIDQRGYDGR NALRVAALEG HRDIVELLFS HGADVNCKDA DGRPTLYILA 910 920 930 940 950 960 LENQLTMAEY FLENGANVEA SDAEGRTALH VSCWQGHMEM VQVLIAYHAD VNAADNEKRS 970 980 990 1000 1010 1020 ALQSAAWQGH VKVVQLLIEH GAVVDHTCNQ GATALCIAAQ EGHIDVVQVL LEHGADPNHA 1030 1040 1050 1060 1070 1080 DQFGRTAMRV AAKNGHSQII KLLEKYGASS LNGCSPSPVH TMEQKPLQSL SSKVQSLTIK 1090 1100 1110 1120 1130 1140 SNSSGSTGGG DMQPSLRGLP NGPTHAFSSP SESPDSTVDR QKSSLSNNSL KSSKNSSLRT 1150 1160 1170 1180 1190 1200 TSSTATAQTV PIDSFHNLSF TEQIQQHSLP RSRSRQSIVS PSSTTQSLGQ SHNSPSSEFE 1210 1220 1230 1240 1250 1260 WSQVKPSLKS TKASKGGKSE NSAKSGSAGK KAKQSNSSQP KVLEYEMTQF DRRGPIAKSG 1270 1280 1290 1300 1310 1320 TAAPPKQMPA ESQCKIMIPS AQQEIGRSQQ QFLIHQQSGE QKKRNGIMTN PNYHLQSNQV 1330 1340 1350 1360 1370 FLGRVSVPRT MQDRGHQEVL EGYPSSETEL SLKQALKLQI EGSDPSFNYK KETPL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus.
[2]	The German cDNA consortium Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 96-1375. Tissue: Colon endothelium.
[3]	"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O. DNA Res. 6:337-345(1999) [PubMed: 10574462] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 287-1375. Tissue: Brain.
[4]	Bienvenut W.V., Dhillon A.S., Kolch W. Submitted (FEB-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 439-448 AND 762-777, MASS SPECTROMETRY. Tissue: Hepatoma.
[5]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1168, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK127496 mRNA. Translation: BAC87007.1. BX640674 mRNA. Translation: CAE45806.1. AB033049 mRNA. Translation: BAA86537.2.
RefSeq	NP_065070.1.
UniGene	Hs.480694 Hs.648024
3D structure databases
HSSP	HSSP built from PDB template 1DC2 based on UniProtKB P42771.
ModBase	Search...
PTM databases
PhosphoSite	Q9ULJ7.
Genome annotation databases
Ensembl	ENSG00000151458. Homo sapiens. [Contig view]
GeneID	57182.
KEGG	hsa:57182.
Organism-specific databases
HGNC	HGNC:29223. ANKRD50.
PharmGKB	PA128394695.
HUGE	Search...
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	Q9ULJ7.
HOVERGEN	Q9ULJ7.
Gene expression databases
ArrayExpress	Q9ULJ7.
CleanEx	HS_ANKRD50.
GermOnline	ENSG00000151458. Homo sapiens.
Family and domain databases
InterPro	IPR002110. ANK. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 3 hits.
Pfam	PF00023. Ank. 19 hits. [Graphical view]
PRINTS	PR01415. ANKYRIN.
SMART	SM00248. ANK. 17 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 17 hits. [Graphical view]
ProDom	Q9ULJ7. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ANR50_HUMAN

Accession

Primary (citable) accession number: Q9ULJ7
Secondary accession number(s): Q6N064, Q6ZSE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	March 7, 2006
Last modified:	July 22, 2008
This is version 53 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)