Anaphase-promoting complex subunit 10

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Reviewed, UniProtKB/Swiss-Prot Q9UM13 (APC10_HUMAN)

Last modified July 22, 2008. Version 61. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Anaphase-promoting complex subunit 10
      Short name=APC10
Alternative name(s):
    Cyclosome subunit 10

Gene names

Name:	ANAPC10
Synonyms:	APC10

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.

Subunit structure

The APC is composed of at least 11 subunits. The C-terminus of APC10 binds to CDC27/APC3.

Sequence similarities

Belongs to the APC10 family.

Contains 1 DOC domain.

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Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis Ubl conjugation pathway
Coding sequence diversity	Polymorphism
Technical term	3D-structure
Gene Ontology (GO)
Biological process	G2/M transition of mitotic cell cycle Ref.1 Traceable author statement. Source: ProtInc anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Inferred from Experiment. Source: Reactome mitotic anaphase Ref.1 Traceable author statement. Source: ProtInc negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle Inferred from Experiment. Source: Reactome positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle Inferred from Experiment. Source: Reactome
Cellular component	anaphase-promoting complex Ref.1 Non-traceable author statement. Source: UniProtKB cytosol Inferred from Experiment. Source: Reactome nucleoplasm Inferred from Experiment. Source: Reactome
Molecular function	protein binding Ref.1 Non-traceable author statement. Source: UniProtKB ubiquitin-protein ligase activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Molecule processing

Chain

1 – 185

185

Anaphase-promoting complex subunit 10

Regions

Domain

1 – 185

185

DOC

Natural variations

Natural variant

R → Q

Experimental info

Sequence conflict

K → R in AAD30527. Ref.1

Sequence conflict

134

T → S in CAB45705. Ref.3

Sequence conflict

146

Q → L in CAB45705. Ref.3

Secondary structure

185

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9UM13-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: ACA7F245B3861FF5
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FASTA

185

21,252

        10         20         30         40         50         60 
MTTPNKTPPG ADPKQLERTG TVREIGSQAV WSLSSCKPGF GVDQLRDDNL ETYWQSDGSQ 

        70         80         90        100        110        120 
PHLVNIQFRR KTTVKTLCIY ADYKSDESYT PSKISVRVGN NFHNLQEIRQ LELVEPSGWI 

       130        140        150        160        170        180 
HVPLTDNHKK PTRTFMIQIA VLANHQNGRD THMRQIKIYT PVEESSIGKF PRCTTIDFMM 


YRSIR

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex." Grossberger R., Gieffers C., Zachariae W., Podtelejnikov A.V., Schleiffer A., Nasmyth K., Mann M., Peters J.-M. J. Biol. Chem. 274:14500-14507(1999) [PubMed: 10318877] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of human APC10/Doc1 as a subunit of anaphase promoting complex." Kurasawa Y., Todokoro K. Oncogene 18:5131-5137(1999) [PubMed: 10498862] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N., Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A. Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-46.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex." Wendt K.S., Vodermaier H.C., Jacob U., Gieffers C., Gmachl M., Peters J.-M., Huber R., Sondermann P. Nat. Struct. Biol. 8:784-788(2001) [PubMed: 11524682] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).
[7]	"Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C." Dube P., Herzog F., Gieffers C., Sander B., Riedel D., Mueller S.A., Engel A., Peters J.-M., Stark H. Mol. Cell 20:867-879(2005) [PubMed: 16364912] [Abstract] Cited for: ELECTRON MICROSCOPY OF THE APC/C.

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Cross-references

Sequence databases

AF132794 mRNA. Translation: AAD30527.1.
AB012109 mRNA. Translation: BAA86953.1.
AL080090 mRNA. Translation: CAB45705.1.
DQ304649 Genomic DNA. Translation: ABB96248.1.
BC005217 mRNA. Translation: AAH05217.1.

PIR

T12476.

RefSeq

NP_055700.2.

UniGene

Hs.480876

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JHJ	X-ray	1.60	A	3-172	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9UM13.

PTM databases

PhosphoSite

Q9UM13.

Polymorphism databases

NIEHS-SNPs

Search...

Genome annotation databases

Ensembl

ENSG00000164162. Homo sapiens. [Contig view]

GeneID

10393.

KEGG

hsa:10393.

Organism-specific databases

H-InvDB

HIX0004537.
HIX0037099.

HGNC

HGNC:24077. ANAPC10.

PharmGKB

PA134938672.

GenAtlas

Search...

GeneCards

Search...

Phylogenomic databases

HOGENOM

Q9UM13.

HOVERGEN

Q9UM13.

Enzyme and pathway databases

Reactome

REACT_152. Cell Cycle, Mitotic.
REACT_1538. Cell Cycle Checkpoints.
REACT_6850. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
REACT_8017. APC-Cdc20 mediated degradation of Nek2A.
REACT_9035. APC/C:Cdh1-mediated degradation of Skp2.

Gene expression databases

ArrayExpress

Q9UM13.

CleanEx

HS_ANAPC10.

GermOnline

ENSG00000164162. Homo sapiens.

Family and domain databases

InterPro

IPR004939. APC10.
IPR016901. APC10_sub.
[Graphical view]

PANTHER

PTHR12936. APC10. 1 hit.

Pfam

PF03256. APC10. 1 hit.
[Graphical view]

PIRSF

PIRSF028841. APC10_sub. 1 hit.

PROSITE

PS51284. DOC. 1 hit.
[Graphical view]

BLOCKS

Search...

Other Resources

LinkHub

Q9UM13.

ProtoNet

Search...

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Entry information

Entry name

APC10_HUMAN

Accession

Primary (citable) accession number: Q9UM13
Secondary accession number(s): Q2V500, Q9UG51, Q9Y5R0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	May 1, 2000
Last modified:	July 22, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Keywords

Gene Ontology (GO)

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents