Reviewed, UniProtKB/Swiss-Prot Q9UPW5 (CBPC1_HUMAN)

Names and origin

Protein names

Recommended name:
    Cytosolic carboxypeptidase 1
    EC=3.4.17.-
Alternative name(s):
    ATP/GTP-binding protein 1
    Nervous system nuclear protein induced by axotomy

Gene names

Name:	AGTPBP1
Synonyms:	CCP1, KIAA1035, NNA1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1226 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in the processing of tubulin By similarity.
Cofactor	Binds 1 zinc ion per subunit Potential.
Subcellular location	CytoplasmBy similarity. NucleusBy similarity.
Sequence similarities	Belongs to the peptidase M14 family.
Sequence caution	BAA82987.2 sequence differs from that shown. Reason: Frameshift at position 10.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Metal-binding Zinc
Molecular function	Carboxypeptidase Hydrolase Metalloprotease Protease
PTM	Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9UPW5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9UPW5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     304-343: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 1226	1226	Cytosolic carboxypeptidase 1
Sites
	Active site	970	1	Nucleophile By similarity
	Metal binding	920	1	Zinc By similarity
	Metal binding	923	1	Zinc By similarity
	Metal binding	1017	1	Zinc By similarity
Amino acid modifications
	Modified residue	1168	1	Phosphoserine
Natural variations
	Alternative sequence	304 – 343	40	Missing in isoform 2.
	Natural variant	423	1	E → K in a colorectal cancer sample; somatic mutation.
Experimental info
	Sequence conflict	274	1	Q → R in BAA91749. Ref.3
	Sequence conflict	398 – 399	2	DI → KK in CAH56222. Ref.7
	Sequence conflict	464	1	E → G in BAA91749. Ref.3
	Sequence conflict	495	1	M → V in BAB14505. Ref.3
	Sequence conflict	574	1	M → V in BAB14100. Ref.3
	Sequence conflict	598	1	E → G in BAA91749. Ref.3
	Sequence conflict	712	1	F → I in CAH56222. Ref.7
	Sequence conflict	756	1	M → T in BAB14100. Ref.3
	Sequence conflict	812	1	S → P in BAB14505. Ref.3
	Sequence conflict	830	1	T → A in CAH56158. Ref.7
	Sequence conflict	909	1	N → D in BAB14505. Ref.3
	Sequence conflict	1054	1	Y → F in BAB14505. Ref.3
	Sequence conflict	1153	1	L → P in CAH56158. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 23, 2007. Version 3. Checksum: A6D598D11D2BD1F8	FASTA	1,226	138,448
	10 20 30 40 50 60 MSKLKVIPEK SLTNNSRIVG LLAQLEKINA EPSESDTARY VTSKILHLAQ SQEKTRREMT 70 80 90 100 110 120 AKGSTGMEIL LSTLENTKDL QTTLNILSIL VELVSAGGGR RVSFLVTKGG SQILLQLLMN 130 140 150 160 170 180 ASKESPPHED LMVQIHSILA KIGPKDKKFG VKARINGALN ITLNLVKQNL QNHRLVLPCL 190 200 210 220 230 240 QLLRVYSANS VNSVSLGKNG VVELMFKIIG PFSKKNSSLI KVALDTLAAL LKSKTNARRA 250 260 270 280 290 300 VDRGYVQVLL TIYVDWHRHD NRHRNMLIRK GILQSLKSVT NIKLGRKAFI DANGMKILYN 310 320 330 340 350 360 TSQECLAVRT LDPLVNTSSL IMRKCFPKNR LPLPTIKSSF HFQLPVIPVT GPVAQLYSLP 370 380 390 400 410 420 PEVDDVVDES DDNDDIDVEA ENETENEDDL DQNFKNDDIE TDINKLKPQQ EPGRTIEDLK 430 440 450 460 470 480 MYEHLFPELV DDFQDYDLIS KEPKPFVFEG KVRGPIVVPT AGEETSGNSG NLRKVVMKEN 490 500 510 520 530 540 ISSKGDEGEK KSTFMDLAKE DIKDNDRTLQ QQPGDQNRTI SSVHGLNNDI VKALDRITLQ 550 560 570 580 590 600 NIPSQTAPGF TAEMKKDCSL PLTVLTCAKA CPHMATCGNV LFEGRTVQLG KLCCTGVETE 610 620 630 640 650 660 DDEDTESNSS VEQASVEVPD GPTLHDPDLY IEIVKNTKSV PEYSEVAYPD YFGHIPPPFK 670 680 690 700 710 720 EPILERPYGV QRTKIAQDIE RLIHQSDIID RVVYDLDNPN YTIPEEGDIL KFNSKFESGN 730 740 750 760 770 780 LRKVIQIRKN EYDLILNSDI NSNHYHQWFY FEVSGMRPGV AYRFNIINCE KSNSQFNYGM 790 800 810 820 830 840 QPLMYSVQEA LNARPWWIRM GTDICYYKNH FSRSSVAAGG QKGKSYYTIT FTVNFPHKDD 850 860 870 880 890 900 VCYFAYHYPY TYSTLQMHLQ KLESAHNPQQ IYFRKDVLCE TLSGNSCPLV TITAMPESNY 910 920 930 940 950 960 YEHICHFRNR PYVFLSARVH PGETNASWVM KGTLEYLMSN NPTAQSLRES YIFKIVPMLN 970 980 990 1000 1010 1020 PDGVINGNHR CSLSGEDLNR QWQSPSPDLH PTIYHAKGLL QYLAAVKRLP LVYCDYHGHS 1030 1040 1050 1060 1070 1080 RKKNVFMYGC SIKETVWHTN DNATSCDVVE DTGYRTLPKI LSHIAPAFCM SSCSFVVEKS 1090 1100 1110 1120 1130 1140 KESTARVVVW REIGVQRSYT MESTLCGCDQ GKYKGLQIGT RELEEMGAKF CVGLLRLKRL 1150 1160 1170 1180 1190 1200 TSPLEYNLPS SLLDFENDLI ESSCKVTSPT TYVLDEDEPR FLEEVDYSAE SNDELDIELA 1210 1220 ENVGDYEPSA QEEVLSDSEL SRTYLP
	Isoform 2 [UniParc]. Checksum: D5361B66224C04BE		1,186	133,864
	10 20 30 40 50 60 MSKLKVIPEK SLTNNSRIVG LLAQLEKINA EPSESDTARY VTSKILHLAQ SQEKTRREMT 70 80 90 100 110 120 AKGSTGMEIL LSTLENTKDL QTTLNILSIL VELVSAGGGR RVSFLVTKGG SQILLQLLMN 130 140 150 160 170 180 ASKESPPHED LMVQIHSILA KIGPKDKKFG VKARINGALN ITLNLVKQNL QNHRLVLPCL 190 200 210 220 230 240 QLLRVYSANS VNSVSLGKNG VVELMFKIIG PFSKKNSSLI KVALDTLAAL LKSKTNARRA 250 260 270 280 290 300 VDRGYVQVLL TIYVDWHRHD NRHRNMLIRK GILQSLKSVT NIKLGRKAFI DANGMKILYN 310 320 330 340 350 360 TSQLPVIPVT GPVAQLYSLP PEVDDVVDES DDNDDIDVEA ENETENEDDL DQNFKNDDIE 370 380 390 400 410 420 TDINKLKPQQ EPGRTIEDLK MYEHLFPELV DDFQDYDLIS KEPKPFVFEG KVRGPIVVPT 430 440 450 460 470 480 AGEETSGNSG NLRKVVMKEN ISSKGDEGEK KSTFMDLAKE DIKDNDRTLQ QQPGDQNRTI 490 500 510 520 530 540 SSVHGLNNDI VKALDRITLQ NIPSQTAPGF TAEMKKDCSL PLTVLTCAKA CPHMATCGNV 550 560 570 580 590 600 LFEGRTVQLG KLCCTGVETE DDEDTESNSS VEQASVEVPD GPTLHDPDLY IEIVKNTKSV 610 620 630 640 650 660 PEYSEVAYPD YFGHIPPPFK EPILERPYGV QRTKIAQDIE RLIHQSDIID RVVYDLDNPN 670 680 690 700 710 720 YTIPEEGDIL KFNSKFESGN LRKVIQIRKN EYDLILNSDI NSNHYHQWFY FEVSGMRPGV 730 740 750 760 770 780 AYRFNIINCE KSNSQFNYGM QPLMYSVQEA LNARPWWIRM GTDICYYKNH FSRSSVAAGG 790 800 810 820 830 840 QKGKSYYTIT FTVNFPHKDD VCYFAYHYPY TYSTLQMHLQ KLESAHNPQQ IYFRKDVLCE 850 860 870 880 890 900 TLSGNSCPLV TITAMPESNY YEHICHFRNR PYVFLSARVH PGETNASWVM KGTLEYLMSN 910 920 930 940 950 960 NPTAQSLRES YIFKIVPMLN PDGVINGNHR CSLSGEDLNR QWQSPSPDLH PTIYHAKGLL 970 980 990 1000 1010 1020 QYLAAVKRLP LVYCDYHGHS RKKNVFMYGC SIKETVWHTN DNATSCDVVE DTGYRTLPKI 1030 1040 1050 1060 1070 1080 LSHIAPAFCM SSCSFVVEKS KESTARVVVW REIGVQRSYT MESTLCGCDQ GKYKGLQIGT 1090 1100 1110 1120 1130 1140 RELEEMGAKF CVGLLRLKRL TSPLEYNLPS SLLDFENDLI ESSCKVTSPT TYVLDEDEPR 1150 1160 1170 1180 FLEEVDYSAE SNDELDIELA ENVGDYEPSA QEEVLSDSEL SRTYLP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:197-205(1999) [PubMed: 10470851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[7]	The German cDNA consortium Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 396-1226. Tissue: Lymph node and Oesophageal carcinoma.
[8]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1168, MASS SPECTROMETRY. Tissue: Epithelium.
[9]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-423.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB028958 mRNA. Translation: BAA82987.2. Frameshift. AK001544 mRNA. Translation: BAA91749.1. AK022562 mRNA. Translation: BAB14100.1. Different initiation. AK023280 mRNA. Translation: BAB14505.1. Different initiation. AL157882, AL451131 Genomic DNA. Translation: CAH71213.1. AL157882, AL451131 Genomic DNA. Translation: CAH71214.1. AL451131, AL157882 Genomic DNA. Translation: CAH72317.1. AL451131, AL157882 Genomic DNA. Translation: CAH72318.1. CH471089 Genomic DNA. Translation: EAW62694.1. CH471089 Genomic DNA. Translation: EAW62698.1. BC060815 mRNA. Translation: AAH60815.1. BX648366 mRNA. Translation: CAH56158.1. AL833359 mRNA. Translation: CAH56222.1. Different initiation.
RefSeq	NP_056054.2.
UniGene	Hs.494321
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M14.028.
PTM databases
PhosphoSite	Q9UPW5.
Genome annotation databases
Ensembl	ENSG00000135049. Homo sapiens. [Contig view]
GeneID	23287.
KEGG	hsa:23287.
Organism-specific databases
HGNC	HGNC:17258. AGTPBP1.
MIM	606830. gene.
PharmGKB	PA24630.
HUGE	Search...
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOVERGEN	Q9UPW5.
Gene expression databases
ArrayExpress	Q9UPW5.
CleanEx	HS_AGTPBP1.
Family and domain databases
InterPro	IPR000834. Peptidase_M14. [Graphical view]
Pfam	PF00246. Peptidase_M14. 1 hit. [Graphical view]
ProDom	Q9UPW5. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

CBPC1_HUMAN

Accession

Primary (citable) accession number: Q9UPW5
Secondary accession number(s): Q5VV80 , Q63HM7, Q658P5, Q6P9D6, Q9H8U6, Q9H9W8, Q9NVK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	July 22, 2008
This is version 42 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)