Reviewed, UniProtKB/Swiss-Prot Q9VSY6 (SERB_DROME)

Names and origin

Protein names

Recommended name:
    Phosphoserine phosphatase
      Short name=PSPase
      Short name=PSP
    EC=3.1.3.3
Alternative name(s):
    O-phosphoserine phosphohydrolase

Gene names

Name:	aay
Synonyms:	astray
ORF Names:	CG3705

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates By similarity.
Catalytic activity	O-phospho-L(or D)-serine + H(2)O = L(or D)-serine + phosphate.
Cofactor	Magnesium By similarity.
Developmental stage	Expressed in a complex banded pattern early in embryogenesis. During maturation of the embryo, expression becomes restricted to cells around and of the gut.
Sequence similarities	Belongs to the serB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Serine biosynthesis
Ligand	Magnesium
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine biosynthetic process Ref.1 Non-traceable author statement. Source: FlyBase axon guidance Ref.1 Inferred from mutant phenotype. Source: FlyBase peripheral nervous system development Ref.1 Traceable author statement. Source: FlyBase
Molecular function	phosphoserine phosphatase activity Ref.1 Non-traceable author statement. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 270	270	Phosphoserine phosphatase
Experimental info
	Sequence conflict	22	1	T → A in AAF14696. Ref.1
	Sequence conflict	217	1	S → N in AAF14696. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9VSY6-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 5B9DC00608EB59FA	FASTA	270	29,218
	10 20 30 40 50 60 MSGSVLSLAR PAAATNGHNL LTKQLNCNGN GTTGGAAKTT VASAITPPKQ PQLAAKVIQQ 70 80 90 100 110 120 SQIVCFDVDS TVICEEGIDE LAEYCGKGSE VARVTKEAMG GAMTFQDALK IRLNIIRPTQ 130 140 150 160 170 180 QQVRDFIQER PSTLSKNVKR FVSHLKAEGK QVYLISGGFD CLIAPVANEL GIPLKNVYAN 190 200 210 220 230 240 KMLFDYLGEY DSFDINQPTS RSGGKAEAIA LIRKENSDDS LITMIGDGAT DLEAVPPANY 250 260 270 FIGFGGNVVR PEVYRRAQYY VTDFEQLMGQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins." Prokopenko S.N., He Y., Lu Y., Bellen H.J. Genetics 156:1691-1715(2000) [PubMed: 11102367] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF191498 mRNA. Translation: AAF14696.1. AE014296 Genomic DNA. Translation: AAF50274.1. AY051689 mRNA. Translation: AAK93113.1.
RefSeq	NP_524001.2.
UniGene	Dm.2900
3D structure databases
HSSP	HSSP built from PDB template 1NNL based on UniProtKB P78330.
ModBase	Search...
Genome annotation databases
Ensembl	CG3705. Drosophila melanogaster. [Contig view]
GeneID	39085.
KEGG	dme:Dmel_CG3705.
NMPDR	fig|7227.3.peg.9062.
Organism-specific databases
FlyBase	FBgn0023129. aay.
Phylogenomic databases
HOGENOM	Q9VSY6.
Gene expression databases
ArrayExpress	Q9VSY6.
GermOnline	CG3705. Drosophila melanogaster.
Family and domain databases
InterPro	IPR005834. Dehalogen-like_hydro. IPR006383. HAD-SF_hydro_IB_PSP-like. IPR004469. SerB. [Graphical view]
Pfam	PF00702. Hydrolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01488. HAD-SF-IB. 1 hit. TIGR00338. serB. 1 hit.
ProDom	Q9VSY6. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

SERB_DROME

Accession

Primary (citable) accession number: Q9VSY6
Secondary accession number(s): Q9U4B0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	May 1, 2000
Last modified:	July 22, 2008
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project