Reviewed, UniProtKB/Swiss-Prot Q9WTV8 (V1AR_MICMA)

Names and origin

Protein names

Recommended name:
    Vasopressin V1a receptor
      Short name=V1aR
Alternative name(s):
    Vascular/hepatic-type arginine vasopressin receptor
    Antidiuretic hormone receptor 1a
    AVPR V1a

Gene names

Name:

Avpr1a

Organism

Microtus montanus (Montane vole)

Taxonomic identifier

88450 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Arvicolinae › Microtus

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Miscellaneous	In prairie and pine voles, the 5' regulatory region of AVPR1A contains a microsatellite region that is virtually absent from montane and meadow voles. This species-specific microsatellite polymorphism modulates gene expression in a cell-type-dependent manner and generates a great individual variability in the brain expression pattern. This polymorphism is correlated with monogamous social organization. Prairie voles exhibit a monogamous social structure in nature, whereas closely related meadow voles are solitary and polygamous. AVPR1A is expressed at higher levels in the ventral forebrain of monogamous than in promiscuous vole species, whereas dopamine receptor distribution is relatively conserved between species. The partner preference formation in the socially promiscuous meadow vole is increased by AVPR1A gene transfer into the ventral forebrain.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Lipoprotein Palmitate Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 420	420	Vasopressin V1a receptor
Regions
	Topological domain	1 – 54	54	Extracellular Potential
	Transmembrane	55 – 75	21	1 Potential
	Topological domain	76 – 92	17	Cytoplasmic Potential
	Transmembrane	93 – 113	21	2 Potential
	Topological domain	114 – 125	12	Extracellular Potential
	Transmembrane	126 – 146	21	3 Potential
	Topological domain	147 – 168	22	Cytoplasmic Potential
	Transmembrane	169 – 189	21	4 Potential
	Topological domain	190 – 225	36	Extracellular Potential
	Transmembrane	226 – 246	21	5 Potential
	Topological domain	247 – 294	48	Cytoplasmic Potential
	Transmembrane	295 – 315	21	6 Potential
	Topological domain	316 – 331	16	Extracellular Potential
	Transmembrane	332 – 352	21	7 Potential
	Topological domain	353 – 420	68	Cytoplasmic Potential
Amino acid modifications
	Modified residue	406	1	Phosphoserine By similarity
	Lipidation	367	1	S-palmitoyl cysteine By similarity
	Lipidation	368	1	S-palmitoyl cysteine By similarity
	Glycosylation	27	1	N-linked (GlcNAc...) Potential
	Glycosylation	198	1	N-linked (GlcNAc...) Potential
	Disulfide bond	124 ↔ 205		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9WTV8-1 [UniParc]. Last modified August 30, 2005. Version 2. Checksum: B7F7D53D985E3C88	FASTA	420	47,461
	10 20 30 40 50 60 MSFPRGSYDP AASNSSPRWP LSAEDANSSR EAAGHQKGSD PSGDVRNEEL AKLEIAVLAV 70 80 90 100 110 120 IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQLC WDITYRFRGP 130 140 150 160 170 180 DWLCRVVKHL QVFAMFASAY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IAASWVLSFL 190 200 210 220 230 240 LSTPQYFIFS MIEIEVNNGT KTQDCWATFI QPWGTRAYVT WMTSGVFVVP VVILGTCYGF 250 260 270 280 290 300 ICYHIWRNVR GKTASRQSKG SGEDVAPFHK GLLVTPCVSS VKTISRAKIR TVKMTFVIVT 310 320 330 340 350 360 AYILCWAPFF IVQMWSVWDD NFIWTDSENP SITITALLAS LNSCCNPWIY MFFSGHLLQD 370 380 390 400 410 420 CVQSFPCCQR MVQKFTKDDS DNMSRRQTSY SNNRSPTNST GTWKDSPKSS RSIRFIPVST

References

[1]	"Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole." Young L.J., Nilsen R., Waymire K.G., MacGregor G.R., Insel T.R. Nature 400:766-768(1999) [PubMed: 10466725] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Brain.
[2]	Young L.J., Nilsen R.A., Insel T.R., Dondaldson Z. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 18.
[3]	"Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene." Lim M.M., Wang Z., Olazabal D.E., Ren X., Terwilliger E.F., Young L.J. Nature 429:754-757(2004) [PubMed: 15201909] [Abstract] Cited for: ROLE IN SOCIAL BEHAVIOR.

Web resources

Protein Spotlight

Nature's philanderers - Issue 52 of November 2004

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF070010 Genomic DNA. Translation: AAD20955.2.
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Phylogenomic databases
HOVERGEN	Q9WTV8.
Family and domain databases
InterPro	IPR015076. DUF1856. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR001817. Vasoprsn_rcpt. IPR001224. Vprs_V1A_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. PF08983. DUF1856. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00896. VASOPRESSINR. PR00752. VASOPRSNV1AR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProDom	Q9WTV8. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

V1AR_MICMA

Accession

Primary (citable) accession number: Q9WTV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	August 30, 2005
Last modified:	September 2, 2008
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)