Reviewed, UniProtKB/Swiss-Prot Q9Y305 (ACOT9_HUMAN)

Names and origin

Protein names

Recommended name:
    Acyl-coenzyme A thioesterase 9
      Short name=Acyl-CoA thioesterase 9
    EC=3.1.2.-
Alternative name(s):
    Acyl-CoA thioester hydrolase 9

Gene names

Name:	ACOT9
ORF Names:	CGI-16

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs.
Sequence similarities	Belongs to the acyl coenzyme A hydrolase family.

Ontologies

Keywords
Molecular function	Hydrolase Serine esterase
Gene Ontology (GO)
Biological process	acyl-CoA metabolic process Inferred from sequence or structural similarity. Source: HGNC
Cellular component	mitochondrion Inferred from sequence or structural similarity. Source: HGNC
Molecular function	acetyl-CoA hydrolase activity Inferred from sequence or structural similarity. Source: HGNC protein binding Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 406	406	Acyl-coenzyme A thioesterase 9

Sequences

	Sequence		Length	Mass (Da)
	Q9Y305-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 99ADE404D472CEEB	FASTA	406	46,355
	10 20 30 40 50 60 MRRAPCVRDK LREIVGASTN WRDHVKAMEE RKLLHSFLAK SQDGLPPRRM KDSYIEVLLP 70 80 90 100 110 120 LGSEPELREK YLTVQNTVRF GRILEDLDSL GVLICYMHNK IHSAKMSPLS IVTALVDKID 130 140 150 160 170 180 MCKKSLSPEQ DIKFSGHVSW VGKTSMEVKM QMFQLHGDEF CPVLDATFVM VARDSENKGP 190 200 210 220 230 240 AFVNPLIPES PEEEELFRQG ELNKGRRIAF SSTSLLKMAP SAEERTTIHE MFLSTLDPKT 250 260 270 280 290 300 ISFRSRVLPS NAVWMENSKL KSLEICHPQE RNIFNRIFGG FLMRKAYELA WATACSFGGS 310 320 330 340 350 360 RPFVVAVDDI MFQKPVEVGS LLFLSSQVCF TQNNYIQVRV HSEVASLQEK QHTTTNVFHF 370 380 390 400 TFMSEKEVPL VFPKTYGESM LYLDGQRHFN SMSGPATLRK DYLVEP

References

[1]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed: 10810093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF132950 mRNA. Translation: AAD27725.1.
UniGene	Hs.298885
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9Y305.
Genome annotation databases
Ensembl	ENSG00000123130. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:17152. ACOT9.
PharmGKB	PA142672656.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q9Y305.
HOVERGEN	Q9Y305.
Gene expression databases
ArrayExpress	Q9Y305.
CleanEx	HS_ACOT9.
GermOnline	ENSG00000123130. Homo sapiens.
Family and domain databases
ProDom	Q9Y305. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
ProtoNet	Search...

Entry information

Entry name

ACOT9_HUMAN

Accession

Primary (citable) accession number: Q9Y305

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 8, 2000
Last sequence update:	November 1, 1999
Last modified:	July 22, 2008
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)