Reviewed, UniProtKB/Swiss-Prot Q9Y587 (AP4S1_HUMAN)

Names and origin

Protein names

Recommended name:
    AP-4 complex subunit sigma-1
Alternative name(s):
    Adapter-related protein complex 4 subunit sigma-1
    AP-4 adapter complex subunit sigma-1
    Sigma-1 subunit of AP-4
    Sigma4-adaptin

Gene names

Name:

AP4S1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.
Subunit structure	Adapter-like complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunitAP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1).
Subcellular location	Golgi apparatus › trans-Golgi network. Membrane › coated pit. Note= Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells.
Tissue specificity	Widely expressed.
Sequence similarities	Belongs to the adaptor complexes small subunit family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Coated pit Golgi apparatus Membrane
Gene Ontology (GO)
Molecular function	transporter activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Chain	1 – 144	144	AP-4 complex subunit sigma-1

Sequences

	Sequence		Length	Mass (Da)
	Q9Y587-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 0B620AFBB3B7F8A1	FASTA	144	17,005
	10 20 30 40 50 60 MIKFFLMVNK QGQTRLSKYY EHVDINKRTL LETEVIKSCL SRSNEQCSFI EYKDFKLIYR 70 80 90 100 110 120 QYAALFIVVG VNDTENEMAI YEFIHNFVEV LDEYFSRVSE LDIMFNLDKV HIILDEMVLN 130 140 GCIVETNRAR ILAPLLILDK MSES

References

[1]	"Characterization of a fourth adaptor-related protein complex." Hirst J., Bright N.A., Rous B., Robinson M.S. Mol. Biol. Cell 10:2787-2802(1999) [PubMed: 10436028] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[2]	"Identification and characterization of epsilon-adaptin that constitutes AP-4 clathrin adaptor-related complex." Takatsu H., Sakurai M., Shiba Y., Yoshida Y., Nakayama K. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF155159 mRNA. Translation: AAD43329.1. AB030654 mRNA. Translation: BAA82970.1.
RefSeq	NP_001121598.1.
UniGene	Hs.293411
3D structure databases
HSSP	HSSP built from PDB template 1GW5 based on UniProtKB Q00380.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000100478. Homo sapiens. [Contig view]
GeneID	11154.
KEGG	hsa:11154.
Organism-specific databases
H-InvDB	HIX0020120.
HGNC	HGNC:575. AP4S1.
MIM	607243. gene.
PharmGKB	PA24867.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q9Y587.
Gene expression databases
ArrayExpress	Q9Y587.
CleanEx	HS_AP4S1.
GermOnline	ENSG00000100478. Homo sapiens.
Family and domain databases
InterPro	IPR016635. AP_complex_ssu. IPR000804. Clathrin_sigma/coatomer_zeta. [Graphical view]
Pfam	PF01217. Clat_adaptor_s. 1 hit. [Graphical view]
PIRSF	PIRSF015588. AP_complex_sigma. 1 hit.
PROSITE	PS00989. CLAT_ADAPTOR_S. False negative. [Graphical view]
ProDom	Q9Y587. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
Other Resources
LinkHub	Q9Y587.
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

AP4S1_HUMAN

Accession

Primary (citable) accession number: Q9Y587

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 1, 1999
Last modified:	September 2, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)